喉痛灵制剂中重金属及有害元素与禁用农药残留量测定

Determination of Heavy Metals,Harmful Elements and Prohibited-Pesticide Residues in Houtongling Preparations

目的 检测喉痛灵片和喉痛灵颗粒中重金属及有害元素与禁用农药残留量。方法 采用电感耦合等离子体-质谱(ICP-MS)法测定喉痛灵制剂中铅、镉、砷、铜、钙元素,采用原子荧光(AFS)法测定制剂中汞元素,采用气相色谱串联质谱法(GC-MS/MS)和液相色谱串联质谱(LC-MS/MS)法测定制剂中33种禁用农药残留量。结果 喉痛灵片和喉痛灵颗粒中均含有微量铅、砷、镉、铜、汞、钙,均未检出33种禁用农药。结论 喉痛灵片中重金属及有害元素均在安全限度范围内;部分批次喉痛灵颗粒中汞元素超出安全限度范围,有一定安全隐患,应引起重视。2种喉痛灵制剂中农药残留安全风险较低。

Objective To determine the heavy metals,harmful elements and prohibited-pesticide residues in Houtongling Tablets and Houtongling Granules.Methods The contents of lead,cadmium,arsenic,copper and calcium in the Houtongling preparations were determined by the inductively coupled plasma-mass spectrometry (ICP-MS) method.The content of mercury in the preparations was determined by the atomic fluorescence spectrometry (AFS) method.The residues of 33 prohibited pesticides in the preparations were determined by the gas chromatography-tandem mass spectrometry (GC-MS/MS) and liquid chromatographytandem mass spectrometry (LC-MS/MS) methods.Results Lead,arsenic,cadmium,copper,mercury and calcium were all detected in the Houtongling Tablets and Houtongling Granules,while 33 prohibited pesticides were all not detected in the above preparations.Conclusion The contents of heavy metals and harmful elements in Houtongling Tablets are all within the safe limits,while the content of mercury in some batches of Houtongling Granules is over the safe limit,which has a certain potential risk and should be paid attention to.The safety risks of pesticide residues in the two Houtongling preparations are low.