温肾强心方治疗阳虚水停夹瘀型心肾综合征的临床研究

Study of Wenshen Qiangxin Recipe in the Treatment of Yang Deficiency and Water Stopping and Stasis Type Cardiorenal Syndrome

目的:观察温肾强心方治疗阳虚水停夹瘀型心肾综合征(CRS)的临床疗效。方法:选取2018年1月—2019年10月自贡市第一人民医院收治的CRS病人80例,采用随机数字表法分为对照组与治疗组,各40例。对照组给予西医常规治疗,治疗组在此基础上加用温肾强心方治疗。比较两组总有效率、中医证候积分、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、脑钠肽(BNP)、血肌酐(Scr)、尿素氮(BUN)、肾小球滤过率(GFR)、血清胱抑素C(CysC)及超敏C反应蛋白(hs-CRP)水平。结果:对照组、治疗组总有效率分别为80.0%和95.0%,治疗组明显优于对照组(P<0.05)。两组治疗后中医证候积分、LVEF、LVEDD、LVESD、BNP、Scr、BUN、GFR、CysC、hs-CRP水平均较治疗前明显改善(P<0.01),且治疗组改善程度优于对照组(P<0.01)。两组治疗过程中均未发生明显不良反应和毒副作用。结论:温肾强心方治疗阳虚水停夹瘀型CRS病人,可改善病人心肾功能,降低中医证候积分,提高临床疗效。

Objective:To observe the clinical efficacy of Wenshen Qiangxin Recipe in treating patients with cardiorenal syndrome(CRS).Methods:Eighty CRS patients were randomly divided into control group and treatment group,with 40 patients in each group.The patients in control group were given conventional treatment of Western medicine,and the patients in treatment group were given Wenshen Qiangxin Recipe on the basis of control group.The total effective rate,traditional Chinese medicine(TCM)syndrome integral,left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),brain natriuretic peptide(BNP),serum creatinine(Scr),urea nitrogen(BUN),glomerular filtration rate(GFR),serum cystatin C(CysC),and serum hypersensitive C-reactive protein(hs-CRP)levels were compared between two groups.Results:The total effective rate of control group and treatment group were 80.0%and 95.0%,respectively,and that in the treatment group was significantly better than that in the control group(P<0.05).After treatment,TCM syndrome score,LVEF,LVEDD,LVESD,BNP,Scr,BUN,GFR,CysC,and hs-CRP levels were significantly improved in both groups compared with that before treatment(P<0.01),and the improvement degree of treatment group was better than that of control group(P<0.01).No obvious adverse reactions and toxic side effects occurred in two groups during the treatment.Conclusion:Wenshen Qiangxin Recipe can improve the cardiac and renal function of Yang deficiency and water stopping and stasis type CRS patients,reduce TCM syndrome score,and improve clinical efficacy.