TGF-β信号通路在神经退行性疾病中的作用研究进展

Research Progress on the Role of TGF-β Signaling Pathway in Neurodegenerative Diseases

神经退行性疾病是由于各种原因导致的机体神经元或髓鞘进行性丢失,最终出现功能障碍的一类预后极差且无法治愈的疾病。转化生长因子-β(TGF-β)信号通路可以调控多种细胞过程,包括细胞的生长、分化、凋亡等,在维持机体正常发育和动态平衡中具有重要作用。既往的研究表明,TGF-β信号通路与神经退行性疾病的发生发展与治疗存在密切联系,但其机制仍未完全明确。该文介绍了TGF-β信号通路在多种神经退行性疾病中的最新研究进展,以期为神经退行性疾病的预防、诊断和治疗提供新思路。

Neurodegenerative diseases are a type of diseases with poor prognosis and incurable in which the body’s neurons or myelinations are progressively lost due to various reasons,and eventually dysfunction occurs.TGF-β (transforming growth factor-β) signaling pathway can regulate a variety of cellular processes,including cell growth,cell differentiation,cell apoptosis,etc.,and plays an important role in maintaining normal development and homeostasis of the body.Previous studies have shown that the TGF-β signaling pathway is closely related to the occurrence,development and treatment of neurodegenerative diseases.This paper introduces the latest research progress of TGF-β signaling pathway in various neurodegenerative diseases,in order to provide new ideas for the prevention,diagnosis and treatment of neurodegenerative diseases.