脚桥核参与肌张力障碍发病的研究进展

Research progress on involvement of pedunculopontine tegmental nucleus in dystonia

脚桥核作为中脑脑桥运动区的重要组成部分, 参与运动启动、节律及速度的调控, 并被作为帕金森病脑深部电刺激的治疗新靶点, 用于改善患者的步态及姿势异常。近期研究发现, 脚桥核参与肌张力调控, 并在肌张力障碍的发病中发挥重要作用。文中就脚桥核参与肌张力障碍发病的相关研究进行综述, 旨在为肌张力障碍的治疗提供新靶点。

As the major part of mesencephalic locomotion region,pedunculopontine tegmental nucleus(PPN)participates in motor initiation,rhythmic and speed regulation.In addition,PPN is regarded as a novel deep brain stimulation target for patients with Parkinson′s disease due to its dramatic effect on the gait disturbance and postural instability.However,PPN also has an important role in muscle tone control and dystonia.This review is aimed at summarizing the involvement of PPN in dystonia,providing fundamental for targeting PPN for treatment of dystonia in the future.