肾素原受体调控妊娠及子痫前期发生的作用机制研究进展

Research advances on the regulatory mechanism of(pro)renin receptor in pregnancy and pre-eclampsia

子痫前期是一种妊娠期特有的并发症,严重威胁母婴健康。子痫前期的发病机制尚不明确,多数学者认为与肾素-血管紧张素系统(RAS)异常有关。近年来研究发现,RAS的新成员——肾素原受体(PRR)在妊娠过程中起着调控胎盘发育、维持妊娠的重要作用,并且PRR及其剪切产物可溶性肾素原受体(sPRR)在子痫前期患者血液及胎盘中表达异常,可能成为子痫前期的预测指标之一。因此,本文就PRR及sPRR在正常妊娠和子痫前期中的作用机制进行综述,为PRR及sPRR预测子痫前期发生提供参考。

Pre-eclampsia is an idiopathic disorder of pregnancy,and threatens the health of both mother and fetus seriously.It is believed that the renin-angiotensin system(RAS)is involved in the pathogenesis of pre-eclampsia.Recent studies have found that(pro)renin receptor(PRR),the new member of RAS,plays pivotal roles in regulating placenta development and maintaining pregnancy.PRR and its cleavage product soluble PRR(sPRR)are differentially expressed in plasma and placenta in patients with pre-eclampsia,and may be the potential biomarkers of pre-eclampsia.This paper summarizes the function mechanism of PRR and sPRR in normal pregnancy and pre-eclampsia,in order to provide references for further research on prediction of pre-eclampsia.