PEO-PPO嵌段共聚物抗肿瘤应用研究进展

Progress on Anti-tumor Application of PEO-PPO Block Polymers

聚氧乙烯-聚氧丙烯(PEO-PPO)嵌段共聚物是一种理想并有前途的生物材料,因其优良的生物相容性和两亲性,广泛用于药物传递、疾病诊断和治疗等方面。PEO-PPO嵌段共聚物可通过自组装或与其他材料结合形成不同形态的纳米载体。近年,PEO-PPO嵌段共聚物对肿瘤区域的靶向性、解决肿瘤多药耐药性等问题被深入研究,且基于PEO-PPO-PEO型嵌段共聚醚(EPE型嵌段共聚醚)的多功能药物主动靶向载体在肿瘤治疗中应用越来越广泛,并根据肿瘤微环境的特点设计各种刺激响应型胶束,在抗肿瘤应用中取得重大进展。本文对基于PEO-PPO嵌段共聚物的给药系统在肿瘤治疗中的具体应用进行简要综述。

Poly(ethylene oxide)-poly(propylene oxide)(PEO-PPO)block polymers are ideal and promising biological material,which are widely applied in drug delivery,disease diagnosis and treatment due to their good biocompatibility and amphiphilic properties.PEO-PPO block polymers can form different kinds of nano carriers by self-assembling or combining with other materials.In recent years,the problems of targeting tumor region actively and solving multidrug resistance through applying PEO-PPO block polymers have been deeply studied.Besides,it is widespread to utilize multi-functional drug carriers based on PEO-PPO-PEO block polyethers(EPE block polyethers)in tumor treatment,and various stimulus-responsive micelles are developed according to the characteristics of the tumor microenvironment,resulting in great progress in anti-tumor application.In this paper,the specific applications of drug delivery system based on PEO-PPO block polymers in tumor therapy are briefly reviewed.