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Potential of natural medicines for treatment of osteoporosis:a narrative review 被引量:1

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摘要 OBJECTIVE:To organize the fragmented information available in the literature to describe and summarize the extracts used by natural medicines in the treatment of bone loss,and to provide evidence and support for the potential use of natural medicines in the treatment of osteoporosis.METHODS:A literature survey for relevant information regarding the osteogenesis of Dongkuiguo(Fructus Malvae Verticillatae),Machixian(Herba Portulacae Oleraceae).etc.,was conducted using PubM ed,ScienceDirect,MEDLINE,Springer LINK and Google Scholar electronic databases from the years 2000-2020.RESULTS:Dongkuiguo(Fructus Malvae Verticillatae),Machixian(Herba Portulacae Oleraceae).etc.,both inhibit the activity of osteoclasts and reduce bone resorption by regulation of signaling pathways through interacting with signaling molecules.CONCLUSIONS:In this review,the current knowledge of the novel medicines with osteogenesis properties were summarized and their potential in the treatment of bone loss were demonstrated,but the lack of research on the regulation of the signaling pathway’s mechanism of action,and the corresponding theoretical basis for the application of natural medicines in clinical osteoporosis,made it difficult to be widely applied and promoted in clinical practice.Further experiments with some of the medicines and the mechanisms is needed to realize their potential as osteoporosis treatments.
出处 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2023年第1期198-204,共7页 中医杂志(英文版)
基金 Supported by the National Nature Science Foundation of China(No.81660186,81160134) Yunnan Health Training Project of high level talents(No.L-2017019) the Yunnan province"Ten Thousand People Plan"Famous Medical Special Talents(YNWR-MY-2018-017)。
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