重症监护病房获得性肌无力研究进展

Research progress of intensive care unit-acquired weakness

重症监护病房获得性肌无力(ICUAW)是发生于ICU患者的危重疾病,常累及肢体肌肉及呼吸肌,导致患者脱机困难、住院时间延长及病死率增高,严重影响ICU患者预后。机械通气、脓毒血症、多脏器功能衰竭及全身炎症反应综合征(SIRS)是ICUAW常见致病原因;肠外营养、神经肌肉阻滞剂及大剂量糖皮质激素的使用、制动等也可引起ICUAW。目前,尚无ICUAW早期诊断的金标准及治疗策略。本文就ICUAW相关研究进展进行综述,以期加深临床对ICUAW的认识,并提高临床医生的诊疗能力。

Intensive care unit acquired weakness(ICUAW)is a critical disease in patients in the ICU.ICUAW often involves limb muscles and respiratory muscles,resulting in difficulty in offline difficulties,prolonged hospital stay and increased mortality,which seriously affects the prognosis of patients in the ICU.Mechanical ventilation,sepsis,multiple organ failure and systemic inflammatory response syndrome(SIRS)were the common causes of ICUAW.Parenteral nutrition,neuromuscular blockers and the use of large amounts of corticosteroids,braking,etc.,can also cause ICUAW.At present,there is no golden standard and treatment strategy for early diagnosis of ICUAW.This paper reviewed the research progress of ICUAW in order to deepen the clinical understanding of ICUAW and improve the diagnosis and treatment ability of clinicians.