生化检验在乙型病毒性肝炎肝纤维化中的临床应用价值分析

Analysis of clinical value of biochemical test in liver fibrosis of hepatitis B

目的探讨生化检验在乙型病毒性肝炎肝纤维化中的临床应用价值。方法选取48例乙型病毒性肝炎肝纤维化患者作为观察组,另选择同期体检的48例肝功能正常者作为对照组。所有研究对象均进行生化检验和放射免疫检验,比较两组肝功能指标(透明质酸、Ⅳ型胶原、Ⅲ型前胶原)、血清指标(血清白蛋白、总胆固醇、胆碱酯酶)。结果观察组透明质酸(251.36±22.58)μg/L、Ⅳ型胶原(88.68±14.72)μg/L、Ⅲ型前胶原(247.18±21.67)μg/L高于对照组的(60.12±10.25)、(44.21±11.54)、(65.12±20.72)μg/L,差异有统计学意义(P<0.05)。观察组血清白蛋白(31.75±2.16)g/L、血清总胆固醇(1.04±0.21)mmol/L、血清胆碱酯酶(2476.85±587.69)U/L低于对照组的(40.12±2.54)g/L、(4.92±0.45)mmol/L、(8672.94±617.53)U/L,差异有统计学意义(P<0.05)。结论生化检验和放射免疫的应用可对乙型病毒性肝炎肝纤维化进行鉴别,在此基础上制定针对性诊治方案,推广应用价值高。

Objective To discuss the clinical value of biochemical test in liver fibrosis of hepatitis B.Methods 48 patients with hepatic fibrosis from viral hepatitis B were selected as the observation group,and another 48 patients with normal liver function during the same period were selected as the control group.All study subjects underwent biochemical tests and radioimmunoassay to compare the liver function indexes(hyaluronic acid,typeⅣcollagen,typeⅢprocollagen)and serum indexes(serum albumin,total cholesterol,cholinesterase)between the two groups.Results The hyaluronic acid(251.36±22.58)μg/L,typeⅣcollagen(88.68±14.72)μg/L,and typeⅢprocollagen(247.18±21.67)μg/L in the observation group were higher than(60.12±10.25),(44.21±11.54),and(65.12±20.72)μg/L in the control group,and the differences were statistically significant(P<0.05).The serum albumin(31.75±2.16)g/L,serum cholesterol(1.04±0.21)mmol/L,and serum cholinesterase(2476.85±587.69)U/L in the observation group were lower than(40.12±2.54)g/L,(4.92±0.45)mmol/L,and(8672.94±617.53)U/L in the control group,and the differences were statistically significant(P<0.05).Conclusion The application of biochemical tests and radioimmunoassay can differentiate the liver fibrosis of hepatitis B,and a targeted diagnosis and treatment program can be formulated on this basis,which is of high value in popularization and application.