转化生长因子-β和镍纹样蛋白与2型糖尿病大血管病变的相关性

Associations of transforming growth factor-βand meteorin-like protein with macroangiopathy in type 2 diabetes mellitus

目的 探讨转化生长因子-β(TGF-β)和镍纹样蛋白(Metrnl)与2型糖尿病(T2DM)大血管病变的相关性。方法 选取T2DM患者106例,按颈动脉内中层厚度(CIMT)分为单纯T2DM组50例(CIMT≤1.0 mm)、T2DM合并大血管病变组56例(CIMT>1.0 mm),并随机选取同期体检的健康受试者52例为健康对照组。比较3组外周血清中的TGF-β、Metrnl水平,分析各代谢指标与T2DM大血管病变的相关性。结果 T2DM合并大血管病变组TGF-β、Metrnl水平低于单纯T2DM组和健康对照组,差异有统计学意义(P<0.05);血清TGF-β与Metrnl水平呈正相关(P<0.05);收缩压、吸烟、低密度脂蛋白胆固醇(LDL-C)、HOMA-IR是T2DM大血管病变的危险因素,Mernl、TGF-β是T2DM大血管病变的保护因素(P<0.05);受试者工作特征(ROC)曲线分析结果显示,TGF-β和Metrnl预测的曲线下面积(AUC)分别为0.757、0.846, TGF-β联合Metrnl预测的AUC为0.901。结论 血清TGF-β和Metrnl水平降低与T2DM大血管病变的发生相关,TGF-β联合Metrnl检测对T2DM大血管病变的早期评估具有重要意义。

Objective To investigate the correlations of transforming growth factor-β(TGF-β)and meteorin-like protein(Metrnl)with macroangiopathy in type 2 diabetes mellitus.Methods A total of 106 patients with T2DM were divided into simple T2DM group(n=50,CIMT≤1.0 mm),T2DM combined with macroangiopathy disease group(n=56,CIMT>1.0 mm),and 52 healthy subjects who underwent physical examination at the same time were randomly selected as healthy control group.Metrnl and TGF-βlevels in peripheral serum in three groups were compared.The correlations of metabolic indexes with T2DM macroangiopathy were compared between the three groups.Results The levels of TGF-βand Metrnl in the T2DM combined with macroangiopathy disease group were significantly lower than those in the T2DM simple group and healthy control group(P<0.05);there was a positive correlation between TGF-βand Metrnl level(P<0.05);systolic blood pressure,smoking,low-density lipoprotein cholesterol(LDL-C)and HOMA-IR were risk factors for T2DM macroangiopaopathy,while Metrnl and TGF-βwere protective factors for T2DM macroangiopaopathy(P<0.05);receiver operating characteristic(ROC)curve analysis showed that the area under the curve(AUC)predicted by TGF-βand Metrnl were 0.757 and 0.846,respectively,the AUC predicted by TGF-βcombined with Metrnl was 0.901.Conclusion Serum TGF-βand decreased Metrnl levels are associated with the occurrence of T2DM macrovascular disease.Detection of TGF-βcombined with Metrnl is of great significance for the early evaluation of T2DM macrovascular disease.