母亲饮食回避法与特殊配方奶粉治疗以便血为主要症状牛奶蛋白过敏新生儿的疗效对比

Comparison of Curative Effect between Mother’s Dietary Avoidance Method and Special Formula Milk Powder in the Treatment of Newborns with Milk Protein Allergy,the Main Symptoms of Bloody Stool

目的:探讨在便血主要症状牛奶蛋白过敏(CMPA)新生儿治疗期间,母亲饮食回避法与特殊配方奶粉两种方法的效果对比。方法:以我院2021年1—12月接诊的52例以便血主要症状CMPA新生儿为研究对象,按照入组顺序将其分为A组与B组,分别采取母亲饮食回避法与特殊配方奶粉,对患儿进行持续6个月的追踪,采用国际通用年龄别体质量Z评分(WAZ)、年龄别身高Z评分(LAZ)、首都儿科研究所0~6岁儿童神经心理发育量表于0个月、3个月、6个月进行测评对比,同时关注患儿末期便血治疗效果。结果:治疗3个月时,A组与B组WAZ评分结果为(0.45±0.04)分、(0.43±0.03)分,差异有统计学意义(t=2.040,P<0.05);治疗6个月时,A组与B组WAZ评分结果为(0.54±0.25)分、(0.47±0.18)分,差异有统计学意义(t=1.159,P<0.05);治疗3个月时,A组与B组LAZ评分结果为(0.31±0.03)分、(0.30±0.03)分,差异有统计学意义(t=1.202,P<0.05);治疗6个月时,A组与B组LAZ评分结果为(0.54±0.30)分、(0.48±0.05)分,差异有统计学意义(t=1.006,P<0.05);治疗6个月时,A组与B组认知发育评分结果为(115.04±11.02)分、(111.92±10.53)分,差异有统计学意义(t=1.044,P<0.05);A组与B组新生儿便血症状治疗总有效率为96.15%、100.00%,差异无统计学意义(χ^(2)=0.152,P>0.05)。结论:母亲饮食回避法与特殊配方奶粉两种方法均能够改变患儿的便血症状,但母亲饮食回避法更利于患儿的身心发育。

Objective:To explore the effect of mother’s dietary avoidance method and special formula milk powder during the treatment of newborns with milk protein allergy(CMPA),the main symptom of bloody stool.Methods:52 newborns with CMPA,the main symptom of hematochezia,were treated in our hospital from January 2021 to December 2021.They were divided into group A and group B according to the sequence of enrollment.The infants were followed up for 6 months with the mother’s dietary avoidance method and special formula milk powder,using the international general age-specific body mass Z score(WAZ),age-specific length Z score(LAZ),the neuropsychological development scale for 0~6-year-old children of the Capital Institute of Pediatrics was evaluated and compared at 0,3 and 6 months,and attention was paid to the treatment effect of end-stage hematochezia in children.Results:After 3 months of treatment,the WAZ scores of group A and group B were(0.45±0.04)and(0.43±0.03),with significant difference(t=2.040,P<0.05).After 6 months of treatment,the WAZ scores of group A and group B were(0.54±0.25)and(0.47±0.18),with significant difference(t=1.159,P<0.05).After 3 months of treatment,the LAZ scores of group A and group B were(0.31±0.03)and(0.30±0.03),with significant difference(t=1.202,P<0.05).After 6 months of treatment,the LAZ scores of group A and group B were(0.54±0.30)and(0.48±0.05),with significant difference(t=1.006,P<0.05).After 6 months of treatment,the cognitive development scores of group A and group B were(115.04±11.02)points and(111.92±10.53)points,with a statistically significant difference(t=1.044,P<0.05).The total effective rates of neonatal hematochezia in group A and group B were 96.15%and 100.00%,with no significant difference(χ^(2)=0.152,P>0.05).Conclusion:Both mother’s dietary avoidance method and special formula milk powder can change children’s hematochezia symptoms,but mother’s dietary avoidance method is more conducive to children’s physical and mental development.