脑脊液中miRNAs对胶质瘤诊断价值的Meta分析

A meta-analysis on diagnostic value of miRNAs in cerebrospinal fluid for glioma

目的 系统评价脑脊液中miRNAs对胶质瘤的诊断价值。方法 检索Cochrane图书馆、PubMed、Embase、万方数据库、中国期刊全文数据库和中国维普数据库,检索时间为建库起至2021年3月,收集脑脊液中miRNAs在胶质瘤中诊断价值的文献。采用诊断准确性研究的质量评估方法2(QUADAS-2)对纳入文献进行质量评价,应用Stata 14.0和Meta-Disc 1.4软件进行数据分析。结果 共纳入9篇文献14项研究,累计胶质瘤患者427例,对照组423例。Meta分析结果显示合并灵敏度为0.80(95%CI:0.76~0.84),特异度为0.84(95%CI:0.81~0.88),阳性似然比为5.28(95%CI:3.53~7.89),阴性似然比为0.22(95%CI:0.14~0.35),诊断比值比为29.05(95%CI:15.42~54.76);综合受试者工作特征曲线下面积(AUC)为0.908 3(Q^(*)=0.840 3)。结论 脑脊液中miRNAs在胶质瘤中具有较高的诊断性能,可以作为其潜在的诊断标志物。

Objective To systematically evaluate the diagnostic value of miRNAs in cerebrospinal fluid for glioma.Method Cochrane Library,PubMed,Embase,WanFang Database,China National Knowledge Infrastructure and VIP Database were searched and retrieved.The literature of miRNAs in cerebrospinal fluid for the diagnosis of glioma were obtained from inception to March 2021.Quality assessment of diagnostic accuracy studies-2(QUADAS-2)was used to evaluate the quality of included literature.STATA 14.0 and Meta-Disc 1.4 were used to conduct all statistical analyses.Results A total of 9 articles and 14 studies were included,with 427 patients with glioma and 423 in the control group.Meta analysis showed that the combined sensitivity was 0.80(95%CI:0.76-0.84),the specificity was 0.84(95%CI:0.81-0.88),the positive likelihood ratio was 5.28(95%CI:3.53-7.89),the negative likelihood ratio was 0.22(95%CI:0.14-0.35),and the diagnostic odds ratio was 29.05(95%CI:15.42-54.76).The area under the working characteristic curve(AUC)of the comprehensive subject was 0.9083(Q*=0.8403).Conclusion MiRNAs in cerebrospinal fluid have high diagnostic performance and can be used as potential diagnostic markers for glioma.