酚磺乙胺联合奥美拉唑治疗上消化道出血患者的临床疗效研究

Clinical Efficacy of Phenylethylamine Combined with Omeprazole in the Treatment of Upper Gastrointestinal Bleeding

目的 研究对上消化道出血患者给予酚磺乙胺联合奥美拉唑治疗的临床效果。方法 方便选取2019年1月—2021年12月大冶市人民医院收治的120例上消化道出血患者为研究对象,使用随机数表法分为两组,各60例,在常规治疗基础上给予奥美拉唑治疗为参照组,在参照组基础上联合酚磺乙胺治疗为研究组,对比两组治疗后临床效果、24 h止血率、再出血率与不良反应发生率,并检测两组凝血功能[D-二聚体(D-D)、凝血酶原时间(PT)、凝血酶时间(TT)]、免疫功能(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))指标变化情况。结果 研究组总有效率93.33%、24 h止血率60.00%均高于参照组73.33%、35.00%,再出血率8.33%低于参照组26.67%,差异有统计学意义(χ^(2)=8.640、7.519、6.984,P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。治疗前两组D-D、PT、TT、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)指标对比,差异无统计学意义(P>0.05)。治疗后,研究组凝血功能各指标均低于参照组,免疫功能各指标均优于参照组,差异有统计学意义(P<0.05)。结论 给予上消化道出血患者酚磺乙胺联合奥美拉唑治疗,可显著提升治疗效果和24 h止血率,同时可显著降低再出血率,改善患者凝血功能,提升其免疫功能,且不会增加不良反应发生,促进患者预后恢复。

Objective To study the clinical effect of phenylethylamine combined with omeprazole in the treatment of patients with upper gastrointestinal bleeding.Methods 120 patients with upper gastrointestinal bleeding admitted to Daye People's Hospital from January 2019 to December 2021 were conveniently selected as the research subjects.They were randomly divided into two groups using a random number table method,with 60 patients in each group.Omeprazole was given as the reference group on the basis of routine treatment,and the combination of ethylamine bisulfonate was used as the research group.The clinical efficacy,24-hour hemostasis rate,rebleeding rate,and incidence of adverse reactions were compared between the two groups after treatment,And detect the changes in coagulation function(D-dimer(D-D),prothrombin time(PT),thrombin time(TT),and immune function(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))indicators in both groups.Results The total effective rate of the study group was 93.33%,and the 24-hour hemostasis rate was 60.00%,both higher than the reference group's 73.33%and 35.00%,the rebleeding rate was 8.33%lower than the reference group's 26.67%,and the difference was statistically significant(χ^(2)=8.640,7.519,6.984,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Before treatment,there was no statistically significant difference in D-D,PT,TT,CD4^(+),CD8^(+),CD4^(+)/CD8^(+)indicators between the two groups(P>0.05);after treatment,the coagulation function indicators of the study group were lower than those of the reference group,while the immune function indicators were better than those of the reference group,the difference was statistically significant(P<0.05).Conclusion Treating patients with upper gastrointestinal bleeding with the combination of acetaminophen and omeprazole can significantly improve the treatment effect and 24-hour hemostasis rate,while significantly reducing the rate of rebleeding,improving the patient's coagulation function,enhancing their immune function,and not increasing the occurrence of adverse reactions,promoting patient recovery in the future.