摘要
目的:探究肝癌患者血清长链非编码RNA(lncRNA)肝癌高表达转录本(HULC)与肿瘤分期、淋巴结转移的关系。方法:选取肝癌患者92例作为研究组,另选取体检健康人员50例作为对照组,比较分析两组血清lncRNA HULC表达水平。结果:研究组的lncRNA HULC相对表达水平显著高于对照组,两组比较差异有统计学意义(P<0.05);研究组的肝癌不同分期、不同淋巴结转移程度患者lnRNA HULC相对表达水平差异均有统计学意义(P<0.05),且伴随着肝癌恶性分期程度的增加、转移范围的扩大,lnRNA HULC相对表达增加。结论:肝癌患者高水平lncRNA HULC表达提示较为严重的恶性变程度以及广泛的淋巴结转移。
Objective:To explore the expression level of serum long non-coding RNA(lncRNA)highly up-regulated in liver cancer(HULC)and its relationship with tumor staging and lymph node metastasis in patients with liver cancer.Methods:92 patients with liver cancer were selected as the study group,and 50 healthy persons were selected as the control group.The expression level of serum lncRNA HULC were compared.Results:The relative expression level of lncRNA HULC in the study group was significantly higher than that in the control group,with a statistically significant difference(P<0.05).The relative expression level of lnRNA HULC in patients with different stages of liver cancer and different degrees of lymph node metastasis in the study group were showing statistically significant difference(P<0.05),and the relative expression of lnRNA HULC increased with the increase of malignant stage of liver cancer and the expansion of metastasis range.Conclusion:The high expression level of lncRNA HULC indicates severe malignant lesions and extensive lymph node metastasis in patients with liver cancer.
作者
王慧娜
张静
李月
WANG Huina;ZHANG Jing;LI Yue(Dept.of Pharmacy,the First Affiliated Hospital of Henan University,Kaifeng 475000,China;Oncology department,the First Affiliated Hospital of Henan University,Kaifeng 475000,China)
出处
《华夏医学》
CAS
2023年第2期76-79,共4页
Acta Medicinae Sinica
基金
河南省医学科技攻关计划联合共建项目(LHGJ20200539)。
