摘要
We have developed a practical and mild electrochemical protocol for cyanation and cyanomethylation of trimethylammonium salts through a pathway involving C–N bond cleavage without the need for an exter-nal stoichiometric reducing agent or a sacrificial anode.The reaction employs tosyl cyanide(TsCN)or azido allyl alcohol as the cyanation or cyanomethylation reagent,respectively.It shows high functional group compatibility and can be applied for the cyanation of natural product derivatives.Preliminary mechanistic studies indicate the involvement of a radical addition pathway.
基金
This work was supported by the National Natural Science Foundation of China(22102012)
the Changzhou Science and Technology Plan Applied Basic Research Project(CJ20210159 and CJ20210129)
Henan University.