急性缺血性脑卒中患者血清s-100β、NT-proBNP及cTnI水平变化与其病情进展的关系

Serum S-100 in Patients with Acute Ischemic Strokeβ、Relationship between Changes of NT ProBNP and cTnI Levels and Disease Progression

目的探究急性缺血性脑卒中患者血清s-100β、NT-proBNP(N末端脑钠肽前体)及cTnI(肌钙蛋白I)水平变化与其病情进展的关系;方法选取2019年1月~2022年5月在我院就诊的急性缺血性脑卒中患者共95例作为观察组,另选取同期在我院健康体检的50~70周岁健康人60例作为对照组。根据美国国立卫生研究院卒中量表(NIHSS)将观察组患者分为轻症组与重症组,观察组发病3个月后,使用改良Rankin评分量表(mRs)将患者分为预后良好组与预后不良组。对比轻症组与重症组在发病24h、7d、14d血清s-100β、NT-proBNP、cTnI水平差异,并与对照组相比较;对比预后良好组与预后不良组在发病24h、7d、14d血清s-100β、NT-proBNP、cTnI水平差异;分析患者发病24h血清s-100β、NT-proBNP、cTnI水平与NIHSS评分、mRs评分的相关性;结果(1)观察组24h血清s-100β、NT-proBNP、cTnI水平显著高于对照组(P<0.05);重症组24h、7d、14d血清s-100β、NT-proBNP、cTnI水平显著高于轻症组(P<0.05);(2)预后不良组24h、7d、14d血清s-100β、NT-proBNP、cTnI水平显著高于预后良好组(P<0.05);(3)24h血清s-100β、NT-proBNP、cTnI水平与NIHSS评分、mRs评分正相关;结论急性缺血性脑卒中患者血清s-100β、NT-proBNP、cTnI水平在急性期要显著高于健康人群,其与患者脑损伤程度、神经功能缺损程度正相关,可以作为急性缺血性脑卒中患者病情诊断与预后分析的参考指标。

Objective To investigate the serum S-100 in patients with acute ischemic strokeβ、The relationship between the changes of NT proBNP(N-terminal brain natriuretic peptide precursor)and cTnI(troponin I)levels and the disease progression;Methods a total of 95 patients with acute ischemic stroke who were treated in our hospital from January 2019 to May 2022 were selected as the observation group,and 60 healthy people aged 50 to 70 who were examined in our hospital in the same period were selected as the control group.According to the National Institutes of Health Stroke Scale(NIHSS),the patients in the observation group were divided into mild disease group and severe disease group.Three months after the onset of the disease in the observation group,the patients were divided into good prognosis group and poor prognosis group using the modified Rankin score scale(MRS).The serum levels of S-100 in the mild and severe groups were compared at 24h,7d and 14d after onsetβ、The levels of NT proBNP and cTnI were different and compared with the control group;The serum levels of S-100 in patients with good prognosis were compared with those in patients with poor prognosis at 24 hours,7 days and 14 days after onsetβ、NT proBNP and cTnI levels;The serum S-100 was analyzed in 24 hours after the onset of the diseaseβ、The correlation of NT proBNP and cTnI levels with NIHSS score and Mrs score;Results(1)serum S-100 in the observation group at 24hβ、The levels of NT proBNP and cTnI were significantly higher than those in the control group(P<0.05);Serum S-100 in severe group at 24h,7d and 14dβ、The levels of NT proBNP and cTnI were significantly higher than those in mild group(P<0.05);(2)Serum S-100 in the poor prognosis group at 24h,7d and 14dβ、The levels of NT proBNP and cTnI were significantly higher than those in good prognosis group(P<0.05);(3)24h serum S-100β、NT proBNP and cTnI levels were positively correlated with NIHSS score and Mrs score;Conclusion Serum S-100 in patients with acute ischemic strokeβ、The levels of NT proBNP and cTnI in the acute phase were significantly higher than those in the healthy population,which were positively correlated with the degree of brain injury and neurological impairment of patients,and could be used as a reference index for diagnosis and prognosis analysis of patients with acute ischemic stroke.