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Dendritic cell subsets in cancer immunity and tumor antigen sensing 被引量:9

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摘要 Dendritic cells(DCs)exhibit a specialized antigen-presenting function and play crucial roles in both innate and adaptive immune responses.Due to their ability to cross-present tumor cell-associated antigens to naïve T cells,DCs are instrumental in the generation of specific T-cell-mediated antitumor effector responses in the control of tumor growth and tumor cell dissemination.Within an immunosuppressive tumor microenvironment,DC antitumor functions can,however,be severely impaired.In this review,we focus on the mechanisms of DC capture and activation by tumor cell antigens and the role of the tumor microenvironment in shaping DC functions,taking advantage of recent studies showing the phenotype acquisition,transcriptional state and functional programs revealed by scRNA-seq analysis.The therapeutic potential of DC-mediated tumor antigen sensing in priming antitumor immunity is also discussed.
出处 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2023年第5期432-447,共16页 中国免疫学杂志(英文版)
基金 the Italian Association for Cancer Research(AIRC IG-2017/20776 to SS and IG-2021/25680 to AS) Ministero dell'lstruzione,dell'Universita e della Ricerca(MIUR,PRIN Prot.2017/7J4E75 to SS,2017/8ALPCM_005 to DB) ML was the recipient of a fellowship from AIRC(code 25307).
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