评价左氧氟沙星联合头孢哌酮舒巴坦治疗老年肺炎的临床疗效及对CRP水平的影响

Evaluation of the clinical efficacy of levofloxacin combined with cefoperazone and sulbactam in the treatment of senile pneumonia and its influence on CRP level

目的 分析左氧氟沙星联合头孢哌酮舒巴坦治疗老年肺炎的临床疗效及对C反应蛋白(CRP)水平的影响。方法 110例老年肺炎患者,采用随机数字表法分为对照组及观察组,每组55例。对照组患者给予头孢哌酮舒巴坦治疗,观察组在对照组的基础上增加左氧氟沙星治疗。比较两组患者的住院时间、治疗前后的CRP水平、治疗效果、不良反应发生情况。结果 观察组患者的住院时间为(10.19±2.51)d,短于对照组的(14.34±3.18)d,差异具有统计学意义(P<0.05)。治疗前,两组患者的CRP水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的CRP水平均低于本组治疗前,且观察组患者的CRP水平(15.56±1.21)mg/L低于对照组的(29.12±9.56)mg/L,差异具有统计学意义(P<0.05)。观察组患者的总有效率96.36%高于对照组的83.64%,差异具有统计学意义(P<0.05)。两组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。结论 头孢哌酮舒巴坦联合左氧氟沙星对于老年肺炎的治疗效果确切。

Objective To analyze the clinical efficacy of levofloxacin combined with cefoperazone and sulbactam in the treatment of senile pneumonia and its influence on C-reactive protein(CRP)level.Methods A total of 110 cases of senile pneumonia were divided into control group and observation group according to the random numerical table,with 55 cases in each group.The control group was treated with cefoperazone and sulbactam,and the observation group was treated with levofloxacin on the basis of the control group.The length of hospital stay,the CRP level before and after treatment,the therapeutic effect and the occurrence of adverse reactions were compared between the two groups.Results The length of hospital stay of the observation group was(10.19±2.51)d,which was shorter than that of(14.34±3.18)d of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in CRP levels between the two groups(P>0.05).After treatment,the CRP level in both groups was lower than that before treatment in this group,and the CRP level of(15.56±1.21)mg/L in the observation group was lower than that of(29.12±9.56)mg/L in the control group.The differences were statistical significance(P<0.05).The total effective rate of the observation group was 96.36%,which was higher than that of 83.64%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Cefoperazone and sulbactam combined with levofloxacin has definite therapeutic effect on senile pneumonia.