氯沙坦联合非洛地平对高血压合并慢性肾功能衰竭患者肾功能的影响

Influences of Losartan Combined with Felodipine on Renal Function of Patients with Hypertension and Chronic Renal Failure

目的:探究氯沙坦联合非洛地平对高血压合并慢性肾功能衰竭患者疗效及肾功能的影响。方法:回顾性分析云南省机关事务管理局第一卫生所2019年3月至2021年1月接受治疗的104例高血压合并慢性肾功能衰竭患者,按照治疗方式不同将其分为对照组和观察组,各52例。对照组采用非洛地平治疗,观察组在对照组基础上加用氯沙坦治疗。比较两组患者肾功能指标、血压、血钾水平、临床疗效、不良反应发生情况。结果:治疗后,两组患者舒张压、收缩压、血肌酐、尿素氮、24 h尿蛋白、血钾水平均低于治疗前,且观察组低于对照组,差异具有统计学意义(P <0.05)。观察组患者临床疗效率高于对照组,差异具有统计学意义(P <0.05)。观察组患者不良反应发生率低于对照组,差异具有统计学意义(P <0.05)。结论:对高血压合并慢性肾功能衰竭患者实施氯沙坦联合非洛地平治疗可有效改善其肾功能,提高临床疗效,且安全有效。

Objective To explore the effects of losartan combined with felodipine on renal function of patients with hypertension and chronic renal failure.Methods A retrospective analysis was performed on 104 patients with hypertension combined with chronic renal failure treated in the First Health Institute of Yunnan Provincial Government Offices Administration from March 2019 to January 2021,and they were divided into a control group and an observation group according to different treatment methods,with 52 cases in each group.The control group was treated with felodipine,and the observation group was treated with losartan on the basis of control group.Renal function index,blood pressure,blood potassium level,clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results After treatment,the levels of diastolic blood pressure,systolic blood pressure,blood creatinine,urea nitrogen,24 hours urinary protein and blood potassium in the two groups were lower than those before treatment,and the levels of the above indexes in the observation group was lower than those in the control group,the differences were statistically significant(P<0.05).The clinical efficacy rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The treatment of losartan combined with felodipine in patients with hypertension and chronic renal failure can effectively improve renal function,enhance clinical efficacy,and is safe and effective.