基于毒/效记载演变探讨补骨脂的安全应用研究进展

Research progress in safe use of Psoralea corylifolia based on evolution of toxicity/efficacy

补骨脂具有温肾助阳/补肾健骨的功效,临床多用于骨质疏松、骨折、骨性关节炎等疾病的治疗。随着补骨脂的广泛使用,其不良反应报道不断增多,存在潜在安全风险,影响了补骨脂的临床用药安全。本文从古籍功效/毒性考证、临床不良反应研究、活性成分的药理作用及毒性研究、毒性机制研究、减毒控毒方法等角度对补骨脂毒/效研究进展进行分析,以期为补骨脂及其制剂的临床安全应用提供证据支持。

Psoralea corylifolia L.is a traditional non-toxic Chinese herbal medicine,which is used for the treatment of osteoporosis,fractures,osteoarthritis and other diseases.However,liver injury caused by Chinese herb preparations,including Psoralea corylifolia,is frequently reported over the years,which affects the clinical and safe use of psoralen.This study is expected to provide data for evaluation and prevention of safety risks of Psoralea corylifolia.