颐和春口服液联合西医常规治疗ⅢA型前列腺炎合并不育症的临床研究

Clinical study on Yihechun Oral Liquid combined with conventional western medicine in treatment of type IIIA prostatitis with infertility

目的评价颐和春口服液联合西医常规治疗ⅢA型前列腺炎(肾阳虚型)合并不育症的临床疗效。方法选取2019年11月—2021年1月温州市人民医院就诊的120例患者为研究对象,按照1∶1的比例,随机分为对照组及治疗组,对照组给予生精胶囊联合西医常规治疗,治疗组给予颐和春口服液联合西医常规治疗,疗程均为12周。观察两组的临床疗效,对比两组患者治疗前后的美国国立卫生院慢性前列腺炎症状指数(National Institutes of Health Chronic Prostatitis Symptoms index,NIH-CPSI)评分、中医证候评分、炎症指标、精液常规指标。结果治疗后,治疗组总有效率为96.7%,显著高于对照组的总有效率86.7%(P<0.05)。治疗后,两组NIH-CPSI的疼痛或不适评分、排尿症状评分、生活质量评分、总评分及中医症状评分均显著低于治疗前,且治疗组上述评分显著低于对照组(P<0.05)。治疗后,两组前列腺液白细胞计数、C-反应蛋白、白细胞介素-2水平均显著低于治疗前,且治疗组前列腺液炎症指标水平显著低于对照组(P<0.05)。治疗后,两组精液量、精子密度、精子总数、精子活力、精子存活率均显著高于治疗前,且治疗组精液指标水平显著高于对照组(P<0.05)。两组不良反应情况无显著性差异。结论颐和春口服液联合西医常规治疗ⅢA型前列腺炎(肾阳虚型)合并不育症患者临床疗效好、安全性高,值得临床推广。

Objective To evaluate the clinical efficacy of Yihechun Oral Liquid(颐和春口服液)combined with conventional western medicine in the treatment of type IIIA prostatitis(kidney yang deficiency type)with infertility.Methods A total of 120 patients from November 2019 to January 2021 were randomly divided into control group and treatment group according to the ratio of 1∶1.The control group was given Shengjing Capsule(生精胶囊)combined with conventional western medicine,and the treatment group was given Yihechun Oral Liquid combined with conventional western medicine for 12 weeks.The clinical efficacy of the two groups was observed.The NIH-CPSI score,Chinese medicine symptom score,inflammatory index and semen routine index were compared between the two groups before and after treatment.Results After treatment,the clinical efficacy in the treatment group was 96.7%,which was significantly higher than 86.7%in the control group(P<0.05).After treatment,the pain or discomfort score,urination symptom score,life quality score,and total score of National Institutes of Health Chronic Prostatitis Symptoms index(NIH-CPSI)in both groups were significantly lower than before treatment,and the above scores in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the levels of white blood cell count(WBC),C-reactive protein(CRP),and interleukin-2(IL-2)in both groups were significantly lower than before treatment,and the above inflammatory index in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the semen volume,sperm density,total sperm count,sperm motility and sperm survival rate in both groups were significantly higher than before treatment,and the above semen routine index in the treatment group were significantly higher than those in the control group(P<0.05).There was no significant difference in adverse reactions between the two groups.Conclusion Yinhechun Oral Liquid combined with conventional western medicine in the treatment of type IIIA prostatitis(kidney yang deficiency type)with infertility had good clinical efficacy and high safety,which was worthy of clinical promotion.