miRNAs调控骨关节炎软骨组织的研究进展

Unveiling the Regulatory Role of microRNAs in Cartilage Tissue during Osteoarthritis Progression

微小RNA(miRNAs)是一类重要的非编码RNA分子,对基因表达起负调控作用,对疾病的影响是当下研究的热点问题之一。骨关节炎(OA)是一种常见的慢性关节疾病,发病因素复杂,软骨组织的病变是其主要病因。miRNAs可调控软骨细胞的增殖、凋亡,调节关节软骨细胞外基质的合成和降解,以及抑制软骨细胞的炎症反应等途径。本文通过对OA发病过程中miRNAs调控软骨组织上述生理及病理生理过程的相关研究进行综述,旨在为OA的临床防治提供参考依据。

MicroRNAs(miRNAs)are a critical class of noncoding RNA molecules that play a pivotal role in the modulation of gene expression by suppressing it.The impact of miRNAs on various diseases has emerged as a prominent area of investigation in current scientific research.Osteoarthritis(OA),a prevalent chronic joint disorder,is influenced by numerous pathogenic factors,with alterations in cartilage tissue serving as a primary cause.Studies have revealed that miRNAs actively participate in the physiological processes of cartilage tissue by regulating cellular proliferation,apoptosis,as well as the synthesis and degradation of the extracellular matrix within articular cartilage.Furthermore,they contribute to the suppression of inflammatory reactions in chondrocytes.This paper presents a comprehensive review of research focusing on the regulatory role of miRNAs in cartilage tissue during the pathogenesis of OA,aiming to provide valuable insights for clinical approaches to the prevention and treatment of this condition.