白细胞介素8在骨再生中的作用及机制

Role and mechanism of interleukin-8 in bone regeneration

背景:白细胞介素8是一种重要的细胞因子,研究发现它在骨再生过程中可通过多途径发挥着重要的作用。目的:综合叙述白细胞介素8对骨再生影响的作用机制,为接下来白细胞介素8的研究提供思路。方法:通过检索中国知网数据库(1999年1月至2023年2月)及PubMed数据库(1985年1月至2023年2月)中关于报道白细胞介素8在骨相关细胞及血管化中作用的相关文献,中文检索词为“白细胞介素8,骨修复,骨代谢,间充质干细胞,成骨细胞,破骨细胞,血管化”,英文检索词为“interleukin-8”or“bone repair”or“bone metabolism”or“mesenchymal stem cells”or“osteoblasts”or“osteoclasts”or“vascularization”,初检得到中英文文献508篇,按纳入排除标准共纳入51篇文章进行综述分析。结果与结论:据现有研究显示白细胞介素8能够通过多途径促进骨细胞再生助力骨愈合,其主要分为3个方面:①促进骨细胞及间充质干细胞、成骨细胞等的增殖和分化、促使细胞朝着促进骨愈合的方向发展;②白细胞介素8能够促进血管生成,为骨组织提供充足的营养和氧气,从而进一步提高骨愈合的质量和稳定性;③白细胞介素8有利于缺氧诱导因子1α、血管内皮生长因子、基质金属蛋白酶等的表达,可营造利于骨再生的微环境,从而促进骨组织的再生和修复。综上所述,白细胞介素8在骨愈合中发挥着重要的作用,它能够促进骨细胞增殖和分化、促进血管生成和提高骨再生的机械性能,也能通过破骨细胞、间充质干细胞等作用点影响骨代谢。

BACKGROUND:Interleukin-8 is an important cytokine that has been found to play an important role in bone regeneration through multiple pathways.OBJECTIVE:To comprehensively review the action mechanism of interleukin-8 effects on bone regeneration to provide ideas for the following studies on interleukin-8.METHODS:By searching the China National Knowledge Infrastructure database for articles published from January 1999 to February 2023 and PubMed database for articles published from January 1985 to February 2023 reporting the role of interleukin-8 in bone-associated cells and vascularisation.Chinese and English search terms were“interleukin-8,bone repair,bone metabolism,mesenchymal stem cells,osteoblasts,osteoclasts,vascularization”.The initial review yielded 508 articles in English and Chinese,and a total of 51 articles were included for review and analysis according to the inclusion and exclusion criteria.RESULTS AND CONCLUSION:According to the existing research,interleukin-8 can promote bone cell regeneration and assist bone healing through multiple pathways,which is mainly divided into three aspects:(1)Promote the proliferation and differentiation of bone cells such as mesenchymal stem cells and osteoblasts,and promote the development of cells in the direction of promoting bone healing;(2)interleukin-8 can promote angiogenesis and provide sufficient nutrition and oxygen for bone tissue,thus further improving the quality and stability of bone healing.(3)The appearance of interleukin-8 facilitates the expression of hypoxia-inducible factor-1α,vascular endothelial growth factor,and matrix metalloproteinase,which can create a microenvironment conducive to bone regeneration,thus promoting the regeneration and repair of bone tissue.In summary,interleukin-8 plays an important role in bone healing by promoting osteoblast proliferation and differentiation,facilitating angiogenesis and improving the mechanical properties of bone regeneration,as well as influencing bone metabolism through osteoclasts,mesenchymal stem cells,and other action sites.