摘要
Cardiovascular disease is one of the leading causes of mortality worldwide.Recent studies have shown that circular RNAs(circRNAs)have emerged as important players in the prevention and treatment of cardiovascular diseases.circRNAs are a class of endogenous noncoding RNAs that are generated by back-splicing and are involved in many pathophysiological processes.In this review,we outline the current research progress on the regulatory roles of circRNAs in cardiovascular diseases.Further,new technologies and methods available for identifying,validating,synthesizing,and analyzing circRNAs,as well as their applications in therapeutics,are highlighted here.Moreover,we summarize the increasing insights into the potential use of circRNAs as circulating diagnostic and prognostic biomarkers.Finally,we discuss the prospects and challenges of circRNA therapeutic applications for cardiovascular disease therapy,with a particular focus on developing circRNA synthesis and engineering delivery systems.
出处
《Research》
SCIE
EI
CSCD
2023年第3期389-407,共19页
研究（英文）
基金
the grants from National Key Research and Development Project(2018YFE0113500 to J.X.)
National Natural Science Foundation of China(82020108002 and 82225005 to J.X.and 82270291 to L.W.)
Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-09-E00042 to J.X.)
the grant from Science and Technology Commission of Shanghai Municipality(21XD1421300 and 20DZ2255400 to J.X.)
the“Dawn”Program of Shanghai Education Commission(19SG34 to J.X.)
ZonMw PSIDER grant(no.10250022110004)to J.P.G.S.
