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Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth

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摘要 In 2019,preterm births(PTB)accounted for approximately 0.66 million deaths globally.PTB is also associated with a significantly higher risk of mortality and long-term complications for newborns.Long-term studies associated several factors,including disruption of immune tolerance and inflammation,with PTB.However,the pathogenesis of PTB remains unclear.Gonadal steroid hormones are critical for pregnancy maintenance and regulation of immune and inflammatory responses.However,it is not clear how unbalanced gonadal steroid hormones,such as imbalanced estrogen/androgen or estrogen/progesterone contribute to PTB.In this review,we discuss how gonadal steroid hormones mediate dysfunction in immune tolerance and inflammatory responses,which are known to promote the occurrence of PTB,and provide insight into PTB prediction.
出处 《Maternal-Fetal Medicine》 CSCD 2023年第4期229-237,共9页 母胎医学杂志(英文)
基金 This study was supported by National Natural Science Foundation of China(82001579) Tianjin Health Science and Technology Project(TJWJ2021QN053) Natural Science Foundation of Tianjin(22JCYBJC01110) as well as Open Fund of Tianjin Central Hospital of Gynecology Obstetrics/Tianjin Key Laboratory of human development and reproductive regulation(2022XH10 and 2022XHY03).
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