380例下呼吸道感染住院患者非典型病原体IgM抗体结果分析

Analysis of IgM antibody results of atypical pathogen in 380 hospitalized patients with low⁃er respiratory tract infection

目的 了解380例下呼吸道感染住院患者八种呼吸道非典型病原体的感染情况。方法 应用间接免疫荧光法(IFA)对2018年3月1日至2022年3月1日就诊于聊城市第二人民医院呼吸科的380例呼吸道感染患者血清行八种呼吸道非典型病原体IgM抗体的定性检测,对结果分析。结果 八种呼吸道非典型病原体IgM抗体阳性率为73.95%,MP(18.16%)最多见,2种以上混合阳性率21.58%,最常见的混合感染为MP+LP;春秋季IgM抗体总检出率与冬季相比,差异有统计学意义(χ^(2)=50.10、5.86,P<0.05),其中春季、夏季CP IgM抗体检出率高于冬季,夏季PIVs IgM抗体检出率高于冬季,差异有统计学意义(χ^(2)=6.52、8.43、5.48,P<0.05);14~18、19~45年龄组MP IgM抗体检出率高于46~65、66~99年龄组,66~99年龄组INFB IgM抗体检出率低于其他三个年龄组,差异有统计学意义(χ^(2)=10.22、25.21、5.78、20.63、17.67,P<0.05);女性IgM抗体检测总阳性率及MP IgM抗体阳性率高于男性,差异有统计学意义(χ^(2)=14.25、13.67,P<0.001)。结论 非典型病原体是呼吸道感染的重要病原,下呼吸道感染住院患者以MP、LP为主,混合感染是其特点,部分病原体感染的发生与季节、年龄、性别有关。

Objective To understand the infection of eight respiratory atypical pathogens in 380 hospitalized patients with lower respiratory tract infection.Methods Indirect immunofluorescence method(IFA)was used to qualitatively detect IgM antibodies of eight common respiratory pathogens in serum of 380 patients with respiratory tract infection admitted to the Department of Respiratory Medicine of the Second Peoples Hospital of Liaocheng from March 01,2018 to March 01,2022,and the results were analyzed.Results The positive rate of IgM antibody of eight respiratory pathogens was 73.95%,which MP(18.16%)was the most common,the positive rate of more than two kinds of mixed infection was 21.58%,and the most common mixed infection was MP+LP;Compared with winter,the total detection rate of IgM antibody in spring and autumn is statistically significant(X^(2)=50.10,5.86,P<0.05),among which the detection rate of CP IgM antibody in spring and summer is higher than that in winter,and the detection rate of PIVs IgM antibody in summer is higher than that in winter,the above differences are statistically significant(X^(2)=6.52,8.43,5.48,P<0.05).The detection rate of MP IgM antibody in 14~18 and 19~45 age groups was higher than that in 46~65 and 66~99 age groups,and the detection rate of INFB IgM antibody in 66~99 age group was lower than that in the other three age groups,and the differences were statistically significant(X^(2)=10.22,25.21,5.78,20.63,17.67,P<0.05).The total positive rate and MP IgM antibody of female respiratory pathogen were higher than those of male,the difference was statistically significant(X^(2)=14.25,13.67,P<0.001).Conclusion Atypical pathogens are important pathogens of respiratory tract infection,the hospitalized patients with lower respiratory tract infection were mainly MP and LP,and mixed infection is its characteristic.The occurrence of some pathogen infections is related to season,age and sex.