熊去氧胆酸联合常规西医治疗胆汁反流性胃炎合并幽门螺旋杆菌感染的疗效及对IL-8、PGE2的影响

Efficacy of Ursodeoxycholic Acid and Conventional Western Medicine in Treating Bile Reflux Gastritis Combined with Helicobacter Pylori Infection and Its Effect on IL-8 and PGE2

目的探讨熊去氧胆酸联合常规西医治疗胆汁反流性胃炎(BRG)合并幽门螺旋杆菌(Hp)感染的疗效及对白细胞介素-8(IL-8)、PGE2(前列腺素E2)的影响。方法选取2019年5月—2021年5月巴彦淖尔市医院收治的100例Hp呼吸试验为阳性的BRG患者进行研究,应用随机数表法将其分为观察组与对照组,每组50例。对照组采取常规西医治疗(克拉霉素+奥美拉唑+阿莫西林),观察组在常规西医治疗基础上增加熊去氧胆酸素治疗,对比两组患者临床疗效,并应用酶联免疫吸附法检测治疗前后血清白细胞介素-8(IL-8)、PGE2(前列腺素E2)表达水平,对比胃泌素(GAS)、胃动素(MTL)、胆囊收缩素(CCK)表达水平以及不良反应情况。结果观察组治疗总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后两组患者血清IL-8水平降低,观察组低于对照组,PGE2水平升高,观察组高于对照组(P<0.05);治疗后两组患者血清CCK水平降低,观察组低于对照组,MTL、GAS水平升高,观察组高于对照组,差异有统计学意义(P<0.05);两组患者均无严重不良反应发生,且轻度不良反应比较,差异无统计学意义(P>0.05),但观察组Hp根除率高于对照组(P<0.05)。结论对胆汁反流性胃炎合并Hp感染患者在常规西医治疗的基础上增加熊去氧胆酸能够提升其临床疗效,降低患者炎症反应,提升胃动力,调节胃肠激素,提升Hp根除率,且安全性较高。

Objective To investigate the therapeutic effect of ursodeoxycholic acid and conventional western medicine on bile reflux gastritis(BRG)combined with Helicobacter pylori(Hp)infection and its effect on interleukin-8(IL-8)and prostaglandin E2(PGE2).Methods A total of 100 BRG patients with positive Helicobacter pylori respiratory test admitted in Bayannur City Hospital from May 2019 to May 2021 were selected for the study.They were randomly divided into observation group and control group,with 50 cases in each group.The control group received conventional western treatment(clarithromycin+omeprazole+amoxicillin),and the observation group added ursodeoxycholic acid therapy to conventional western treatment.The clinical efficacy of the two groups was compared.The levels of serum interleukin-8(IL-8),prostaglandin E2(PGE2),gastrin(GAS),motilin(MTL),cholecystokinin(CCK)and adverse reactions were detected by enzyme-linked immunosorbent assay before and after treatment.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05);After treatment,the level of serum IL-8 in the two groups was lower than that in the control group,while the level of PGE2 in the observation group was higher than that in the control group(P<0.05);After treatment,the serum CCK level of the two groups decreased,the level of MTL and GAS in the observation group was lower than that in the control group,and the level of MTL and GAS in the observation group was higher than that in the control group(P<0.05);There was no serious adverse reaction in the two groups,and there was no significant difference in the comparison of mild adverse reactions(P>0.05),but the eradication rate of Hp in the observation group was higher than that in the control group(P<0.05).Conclusion Adding ursodeoxycholic acid on the basis of conventional Western medicine can improve the clinical effect of bile reflux gastritis complicated with Hp infection,reduce the inflammatory reaction of patients,improve gastric motility,regulate gastrointestinal hormones,increase the eradication rate of Hp,and the safety of the drug is better.