江苏省免费孕前优生健康检查乙肝五项室间质评结果分析

Analysis of external quality assessment of laboratories on hepatitis B serological testing for pre-pregnancy health examination in Jiangsu province

目的了解江苏省2012年-2021年免费孕前优生健康检查临床检验实验室乙肝五项血清学检测质量。方法对江苏省参与免费孕前优生健康检查的临床检验实验室,每年开展两次乙肝血清学试验室间质评活动,汇总分析各基层实验室按照要求上报的乙肝五项血清学检测结果。结果2012年-2021年,HBsAg、HBsAb、HBeAg、HBeAb和HBcAb 5个项目室间质评的满分率分别从72.6%、73.7%、94.2%、82.1%、13.7%提高至100%;合格率分别从94.2%、94.2%、94.2%、90.9%和67.4%提高至100%;2017年-2021年室间质评考核成绩合格率和满分率明显高于2012年-2016年,差异有统计学意义(P<0.05);总阳性漏检率分别从9.8%、13.2%、5.8%、16.8%和47.4%降至0%。结论2012年-2021年江苏省免费孕前优生健康检查基层实验室乙肝五项血清学整体检测能力显著提高。

Objective To investigate the level of hepatitis B serological testing in the free pre-pregnancy health examination laboratories from 2012 to 2021 in Jiangsu province.Methods The external quality assessment of hepatitis B serological testing in free pre-pregnancy health examination laboratories was carried out twice a year and each laboratory participating in the external quality assessment,filled in the report and uploaded for statistical analysis.Results From 2012 to 2021,the full mark rate of HBsAg,HBsAb,HBeAg,HBeAb and HBcAb external quality assessment increased from 72.6%、73.7%、94.2%、82.1%and 13.7%to 100%,respectively.The qualified rate of HBsAg,HBsAb,HBeAg,HBeAb and HBcAb external quality assessment increased from 94.2%,94.2%,94.2%,90.9%and 67.4%to 100%,respectively.The qualified rate and full mark rate of the external quality assessment from 2017 to 2021 were significantly higher than those from 2012 to 2016,and the differences were statistically significant(P<0.05).The total positive missed rate of HBsAg,HBsAb,HBeAg,HBeAb and HBcAb external quality assessment decreased from 9.8%,13.2%,5.8%,16.8%and 47.4%to 0%,respectively.Conclusion From 2012 to 2021,the overall serological detection capacity of hepatitis B in grassootsmedical laboratories of free pre-pregnancy health examination in Jiangsu province has been improved.