多因子降维法分析MTHFR C677T基因多态性-Hcy交互作用对高血压合并冠心病的影响

Analysis of the Impact of MTHFR C677T Gene Polymorphism-Hcy Interaction on Hypertension Complicated with Coronary Heart Disease Using Multifactor Dimensionality Reduction

目的:基于多因子降维法(GMDR)分析亚甲基四氢叶酸还原酶(MTHFR)C677T基因多态性-Hcy交互作用对高血压合并冠心病的影响。方法:选取2021年3月至2022年10月我院收治的150例高血压患者作为研究对象,根据冠脉造影结果分为单纯高血压组(n=51)、高血压合并冠心病组(n=99),比较两组一般资料、Hcy水平、MTHFR C677T基因多态性分布,采用Logistic回归方程分析高血压合并冠心病影响因素,采用GMDR分析MTHFR C677T基因多态性与Hcy交互作用。结果:两组MTHFR C677T基因型频率实测值与理论值比较差异无统计学意义(P>0.05);高血压病程、Hcy、LDL-C、MTHFR C677T基因型-TT及等位基因T是高血压合并冠心病影响因素(P<0.05);GMDR结果显示,MTHFR C677T基因型-TT与Hcy交互模型为高血压合并冠心病风险的最优模型,其交叉检验一致性为10/10,检验准确度为75.00%,符合检验值为0.011。结论:MTHFR C677T基因多态性、Hcy交互作用可能增加冠心病发生风险,临床应动态监测上述指标变化情况,及时采取有效治疗措施,减少冠心病发生。

Objective:To analyze the effect of methylene tetrahydrofolate reductase(MTHFR)C677T gene polymorphism-Hcy interaction on hypertension combined with coronary heart disease based on multifactor dimension reduction(GMDR).Methods:A total of 150 hypertensive patients admitted to our hospital from March 2021 to October 2022 were selected as the study subjects.Based on coronary angiography results,they were divided into the isolated hypertension group(n=51)and the hypertension complicated with coronary heart disease group(n=99).General information,Hcy levels,and MTHFR C677T gene polymorphism distribution were compared between the two groups.Logistic regression analysis was used to identify factors influencing hypertension complicated with coronary heart disease,and GMDR was employed to analyze the interaction between MTHFR C677T gene polymorphism and Hcy.Results:There was no statistically significant difference between the observed and theoretical values of MTHFR C677T genotypic frequencies in the two groups(P>0.05).The duration of hypertension,Hcy,LDL-C,MTHFR C677T genotypes(TT),and the T allele were identified as influencing factors for hypertension complicated with coronary heart disease(P<0.05).GMDR results showed that the TT genotype of MTHFR C677T in interaction with Hcy formed the optimal model for the risk of hypertension complicated with coronary heart disease.The cross-validation consistency was 10/10,the testing accuracy was 75.00%,and the sign test P-value was 0.011.Conclusion:MTHFR C677T gene polymorphism and the interaction with Hcy may increase the risk of coronary heart disease.Clinicians should dynamically monitor changes in these indicators and take effective treatment measures promptly to reduce the occurrence of coronary heart disease.