马来酸依那普利叶酸片对高血压伴高同型半胱氨酸血症患者的影响

Effects of Enalapril Maleate Folic Acid Tablets on Patients with Hypertension with Hyperhomocysteinemia

目的:探究马来酸依那普利叶酸片对高血压伴高同型半胱氨酸血症患者的影响。方法:选取2022年1—12月北京市社会福利医院收治的高血压伴高同型半胱氨酸血症患者60例为研究对象,随机将患者分为对照组和观察组,各30例。对照组给予阿托伐他汀联合瑞舒伐他汀治疗,观察组在对照组基础上给予马来酸依那普利叶酸片治疗。比较两组颈动脉斑块面积、不良反应、血压、同型半胱氨酸(Hcy)。结果:治疗后,两组颈总动脉斑块面积、左侧颈动脉斑块面积和右侧颈动脉斑块面积降低,观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);治疗后,两组Hcy水平降低,观察组Hcy水平低于对照组,差异有统计学意义(P<0.05);治疗后,两组舒张压、收缩压水平降低,观察组低于对照组,差异有统计学意义(P<0.05)。结论:马来酸依那普利叶酸片治疗高血压伴高同型半胱氨酸血症患者的效果较好,可减少颈总动脉斑块面积,降低患者血压及Hcy水平,且临床用药安全性高。

Objective:To investigate the effects of enalapril maleate folic acid tablets on patients with hypertension with hyperhomocysteinemia.Methods:Sixty patients with hypertension with hyperhomocysteinemia admitted to Beijing Social Welfare Hospital from January to December 2022 were selected for the study,and the patients were randomly divided into the control group and the observation group,each with thirty cases.The control group was treated with atorvastatin combined with rosuvastatin,and the observation group was treated with enalapril maleate folic acid tablets on the basis of the control group.Carotid plaque area,adverse effects,blood pressure and homocysteine(Hcy)were compared between the two groups.Results:After treatment,the common carotid artery plaque area,left carotid artery plaque area and right carotid artery plaque area decreased in the two groups,and the observation group was lower than the control group,with a statistically significant difference(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05);after treatment,the Hcy levels of the two groups were reduced,and the Hcy level of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05);after treatment,diastolic blood pressure and systolic blood pressure levels were reduced in both groups,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Conclusion:Enalapril maleate folic acid tablets is effective in the treatment of patients with hypertension with hyperhomocysteinemia,which can reduce the area of common carotid artery plaque,lower the patients'blood pressure and Hcy level,and the clinical safety of the drug is high.