Wilm′s tumor gene1肽疫苗Galinpepimut-S在肿瘤免疫治疗中的应用

Application of Wilm′s Tumor Gene1 Peptide Vaccine Galinpepimut-S in Tumor Immunotherapy

目的为Wilm′s tumor gene1(WT1)肽疫苗Galinpepimut-S(GPS)用于肿瘤免疫治疗的后续研究提供参考。方法采用计算机检索中国知网、PubMed等数据库自建库起至2022年12月的肿瘤免疫治疗相关文献,总结GPS在肿瘤免疫治疗中的应用现状。结果GPS能激发自身免疫系统,对WT1抗原产生强烈免疫反应而发挥抗肿瘤作用,在卵巢癌、恶性胸膜间皮瘤、急性髓系白血病、多发性骨髓瘤的治疗中均显示出较好的疗效。结论以GPS为代表的肿瘤疫苗是未来肿瘤治疗的重要方向,需进一步进行临床研究,以获取更多数据。

Objective To provide a reference for the follow-up research of Wilm′s tumor gene1(WT1)peptide vaccine Galinpepimut-S(GPS)for tumor immunotherapy.Methods Tumor immunotherapy-related literature in the CNKI and PubMed databases were searched from the inception to December,and the application of GPS in tumor treatment was summarized.Results GPS can stimulate the autoimmune system to produce a strong immune response to WT1 antigen,and play an anticancer role.It has shown good therapeutic effects in the treatment of ovarian cancer,malignant pleural mesothelioma,acute myeloid leukemia,and multiple myeloma.It has shown good therapeutic effects in ovarian cancer,malignant pleural mesothelioma,acute myeloid leukemia,and multiple myeloma.Conclusion The cancer vaccine represented by GPS is an important direction for future cancer treatment,and further clinical research is needed to obtain more data.