海南沉香灸治疗轻度抑郁性失眠患者的疗效观察

Observation of Therapeutic effect of Hainan Agarwood Moxibustion on Patients with Mild Depressive Insomnia

目的探讨海南沉香灸对轻度抑郁性失眠患者的影响。方法选取2020年11月—2022年1月期间因抑郁性失眠于海南省中医院康复科门诊就诊的85例患者,按随机数字表法分为沉香灸组30例、艾灸组30例、安慰灸组25例。沉香灸组采用针刺、耳穴埋针联合海南沉香灸治疗,艾灸组采用针刺、耳穴埋针联合艾灸治疗,安慰灸组采用针刺、耳穴埋针联合安慰灸治疗。治疗2、4、8周后和随访期间,观察比较两组患者临床疗效及治疗前后汉密尔顿抑郁评分(Hamilton depression score,HAMD)、匹兹堡睡眠质量指数量表评分(Pittsburgh sleep quality index,PSQI)、抑郁自评量表评分(Self-rating depressive scale,SDS)。结果治疗后沉香灸组总有效率93.33%(28/30)、艾灸组总有效率73.33%(22/30)均明显高于安慰灸组44.00%(11/25),差异有统计学意义(P<0.05);且沉香灸组总有效率明显高于艾灸组,差异有统计学意义(P<0.05)。治疗2、4、8周后及随访期间,3组患者HAMD评分均较治疗前降低,差异有统计学意义(P<0.05);沉香灸组和艾灸组HAMD评分均低于安慰灸组,差异有统计学意义(P<0.05);治疗8周后及随访期间,沉香灸组HAMD评分低于艾灸组,差异有统计学意义(P<0.05)。治疗2、4、8周后及随访期间,3组患者PSQI评分均较治疗前降低,差异有统计学意义(P<0.05);沉香灸组和艾灸组PSQI评分均低于安慰灸组,差异有统计学意义(P<0.05);沉香灸组PSQI评分低于艾灸组,差异有统计学意义(P<0.05)。治疗2、4、8周后及随访期间,3组患者SDS评分均较治疗前降低,差异有统计学意义(P<0.05);沉香灸组和艾灸组SDS评分均低于安慰灸组,差异有统计学意义(P<0.05);治疗4、8周后及随访期间,沉香灸组SDS评分均低于艾灸组,差异有统计学意义(P<0.05)。结论沉香灸和艾灸可改善轻度抑郁性失眠患者的抑郁症状和睡眠,沉香灸对抑郁症状和睡眠改善优于艾灸。

Objective To explore the effect of Hainan agarwood moxibustion on patients with mild depressive insomnia.Methods A total of 85 patients with mild depressive insomnia treated in Rehabilitation Department of Hainan Traditional Chinese Medicine Hospital from November 2020 to January 2022 were selected and randomly divided into three groups:Hainan agarwood moxibustion group(30 cases),Artemisia moxibustion group(30 cases)and Placebo moxibustion group(25 cases)using a random number table.The Hainan agarwood moxibustion group was treated with acupuncture,ear point embedding needle combined with Hainan agarwood moxibustion;the moxibustion group was treated with acupuncture,ear point embedding needle combined with Artemisia moxibustion;the Placebo moxibustion group was treated with acupuncture,ear point embedding needle combined with Placebo moxibustion.Clinical efficacy,Hamilton depression(HAMD)score,Pittsburgh sleep quality index(PSQI)score,and self-rating depression scale(SDS)score were observed and compared between the two groups at 2,4,8 weeks after treatment and during the follow-up period.Result The total effective rate after treatment was 93.33%(28/30)in the Agarwood moxibustion group and 73.33%(22/30)in the Artemisia moxibustion group,both significantly higher than the 44.00%(11/25)in the Placebo moxibustion group,with statistically significant difference(P<0.05).The total effective rate of the Agarwood moxibustion group was higher than that of the Artemisia moxibustion group,and the difference was statistically significant(P<0.05).At 2,4,and 8 weeks after treatment and during the follow-up period,the HAMD scores in the three groups were significantly lower than those before treatment(P<0.05).The HAMD scores in the Agarwood Moxibustion group and the Moxibustion with Artemisia group were lower than those in the Placebo Moxibustion group(P<0.05).Additionally,at 8 weeks after treatment and during the follow-up period,the HAMD scores in the Agarwood Moxibustion group were lower than those in the Moxibustion with Artemisia group,with statistically significant differences(P<0.05).Similarly,at 2,4,8 weeks after treatment and during the follow-up period,the PSQI scores in all three groups were significantly lower than those before treatment(P<0.05).The PSQI scores in the Agarwood Moxibustion group and the Moxibustion with Artemisia group were lower than those in the Placebo Moxibustion group(P<0.05).Moreover,the PSQI scores in the Agarwood Moxibustion group were lower than those in the Moxibustion with Artemisia group(P<0.05).The SDS scores in all three groups at 2,4,8 weeks after treatment and during the follow-up period were significantly lower than those before treatment(P<0.05).The SDS scores in the Agarwood Moxibustion group and the Moxibustion with Artemisia group were lower than those in the Placebo Moxibustion group(P<0.05).Additionally,at 4,8 weeks after treatment and during the follow-up period,the SDS scores in the Agarwood Moxibustion group were lower than those in the Moxibustion with Artemisia group(P<0.05).Conclusion Agarwood moxibustion and Artemisia moxibustion can improve the depressive symptoms and sleep of patients with mild depressive insomnia,and agarwood moxibustion is superior to moxibustion in improving depressive symptoms and sleep compared to Artemisia Moxibustion.