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NIR-II fluorescence imaging in liver tumor surgery: A narrative review 被引量:1

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摘要 In liver tumor surgery,the recognition of tumor margin and radical resection of microcancer focis have always been the crucial points to reduce postoperative recurrence of tumor.However,naked-eye inspection and palpation have limited effectiveness in identifying tumor boundaries,and traditional imaging techniques cannot consistently locate tumors in real time.As an intraoperative real-time navigation imaging method,NIRfluorescence imaging has been extensively studied for its simplicity,reliable safety,and superior sensitivity,and is expected to improve the accuracy of liver tumor surgery.In recent years,the research focus of NIRfluorescence has gradually shifted from the-rst near-infrared window(NIR-I,700–900 nm)to the second near-infrared window(NIR-II,1000–1700 nm).Fluorescence imaging in NIR-II reduces the scattering effect of deep tissue,providing a preferable detection depth and spatial resolution while signi-cantly eliminating liver autofluorescence background to clarify tumor margin.Developingfluorophores combined with tumor antibodies will further improve the precision offluorescence-guided surgical navigation.With the development of a bunch offluorophores with phototherapy ability,NIR-II can integrate tumor detection and treatment to explore a new therapeutic strategy for liver cancer.Here,we review the recent progress of NIR-IIfluorescence technology in liver tumor surgery and discuss its challenges and potential development direction.
出处 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2024年第1期29-44,共16页 创新光学健康科学杂志(英文)
基金 supported by the National Key R&D Program of China(No.2020YFA0710700) the National Natural Science Foundation of China(Nos.51873201 and 82172071) Key Research and Development Program of Anhui Province(No.202104b11020025) the Fundamental Research Funds for the Central Universities(No.YD2060002015) the CAS Youth Interdisciplinary Team(No.JCTD-2021-08).
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