斯钙素2在宫颈癌组织中的表达及临床意义

Expression and Clinical Significance of Stanniocalcin 2(STC2)in Cervical Cancer Tissues

目的:探究斯钙素2(STC2)在宫颈癌组织中的表达情况,并评估其临床意义。方法:回顾性选取2022年1月至2023年5月东莞市人民医院宫颈癌患者(n=88)作为研究对象,应用免疫组织化学法测定患者宫颈组织中STC2表达情况,采用实时荧光定量PCR检测STC2,比较宫颈癌组织与癌旁组织STC2 mRNA,分析STC2在不同临床特征宫颈癌中的表达情况,对其相关性进行Logistic回归分析。结果:宫颈癌组织中STC2 mRNA明显高于癌旁组织,差异有统计学意义(P<0.05);宫颈癌组织中STC2阳性表达在年龄、肿瘤直径、病理分型、不同浸润深度、分化程度、TNM分期中差异无统计学意义(P>0.05),STC-2表达与淋巴结转移相关(P<0.05)。多因素Logistic回归分析显示,淋巴结转移是STC-2阳性的独立影响因素;STC2阳性组无进展生存期(PFS)明显低于STC2阴性组,差异有统计学意义(P<0.05)。Pearson分析显示STC2表达与PFS均呈负相关(r=-0.683,P<0.05),由于未达OS终点,目前无法计算以及对比OS差异,后续密切追踪跟进。结论:STC2在宫颈癌组织中表达量高,与年龄、肿瘤直径、病理分型、浸润深度、分化程度、TNM分期无关,与淋巴结转移有关,应予以高度重视。

Objective:To investigate the expression of calcitonin STC2 in cervical cancer tissue and evaluate its clinical significance.Methods:A retrospective study was conducted on cervical cancer patients(n=88)from Dongguan People's Hospital from January 2022to May 2022.Immunohistochemical method was used to determine the expression of STC2 in cervical tissue of patients.Real time fluorescence quantitative PCR was used to detect the gray value of STC2.compare the grayscale values of STC2 mRNA between cervical cancer tissue and normal tissue,analyze the expression of STC2 in different clinical characteristics of cervical cancer,and perform logistic regression analysis on their correlation.Results:The grayscale values of STC2 mRNA in cervical cancer tissues were higher than those in adjacent tissues,with statistical significance(P<0.05);The positive expression of STC2 in cervical cancer tissue showed statistically significant differences in different infiltration depths,differentiation levels,lymph node metastasis,and TNM staging,P<0.05;Multivariate logistic regression analysis showed that depth of infiltration,degree of differentiation,lymph node metastasis,and TNM staging were independent influencing factors for STC2 positivity;The 5-year Overall survival(OS)and Progression-Free Survival(PFS)of the STC2 positive group were lower than those of the STC2 negative group,with a statistically significant difference(P<0.05);Pearson analysis showed that the expression of STC2 was negatively correlated with OS and PFS(r=-0.747,-0.683,P<0.05).Conclusion:STC2 has a high expression in cervical cancer tissues,which has nothing to do with age,tumor diameter,pathological classification,depth of invasion,degree of differentiation and TNM stage,but is related to lymph node metastasis,which should be paid greatattention to.