黄精化学成分、药理作用研究进展及质量标志物预测分析

Research Progress on the Chemical Components and Pharmacological Effects of Polygonati Rhizoma and Prediction Analysis of Its Quality Markers

黄精是常用的补益药,主要炮制品有酒黄精、蒸黄精、蜜黄精。笔者查阅相关文献,对黄精的化学成分、药理作用进行总结。发现黄精的化学成分多样,主要为皂苷类、多糖类、氨基酸类、黄酮类等,经过炮制后其多糖类、皂苷类、氨基酸类、黄酮类、蒽醌类及矿物质成分含量发生明显变化;具有抗衰老、抗氧化、抗糖尿病、抗骨质疏松及免疫调节作用;从传统药性、炮制前后化学成分变化、化学成分可测性方面分析,初步确定黄精多糖、甾体皂苷类、氨基酸类、酚类、黄酮类可作为其质量标志物(Q-Marker)的参考。

Polygonati Rhizoma is a commonly used tonic medicine,the main products are wine processed Polygonati Rhizoma,steam processed Polygonati Rhizoma,and honey processed Polygonati Rhizoma.The authors consulted the relevant literature and summarized the chemical composition and pharmacological action of Polygonati Rhizoma.It was found that the chemical composition of the medicinal was various,mainly including saponins,polysaccharides,amino acids,and flavonoids.After being processed,however,the content of polysaccharide,saponins,amino acids,flavonoids,anthraquinones and mineral components changed significantly,which possess anti-aging,antioxidant,anti diabetes,anti osteoporosis and immunomodulatory effects.From the analysis of traditional medicinal properties,changes in chemical composition before and after processing,and measurability of chemical composition,it is preliminarily determined that polysaccharides,steroidal saponins,amino acids,phenols,and flavonoids from Polygonati Rhizoma can serve as reference for their quality markers(Q-Markers),providing scientific basis for subsequent research.