重构本草——决明子

Reconstruction of Chinese materia medica-cassia seed

通过古籍文献调研、中医药现代研究成果的梳理,结合中医临床及中药学等学科领域内知名专家学者的认识及应用经验,归纳出决明子:功效主要为清热明目,润肠通便。症靶为肥胖、便秘和目赤肿痛。标靶为血脂升高和血压升高。现代药理研究发现决明子及其有效成分具有降血压、降血脂、保护视网膜、通便、护肝、抗菌等作用。决明子主要化学成分大黄素型蒽醌类化合物具有肝肾毒性,临床使用中应注意用量配伍,以免造成或加重肝肾损伤。临床使用剂量为3~60 g,内服时当根据不同疾病,或同一疾病的不同阶段进行辨证使用,并积极探索决明子用量与症靶、标靶的量效关系构建。

Through the investigation of ancient books and the sorting of the modern research achievements of traditional Chinese medicine,combined with the understanding and application experience of well-known experts and scholars in desciplinary fields such as traditional Chinese medicine clinical medicine and science of Chinese materia medica,it is concluded that cassia seed mainly has the effects of clearing heat for improving eyesight,and smoothing intestine and relieving constipation.The symptom targets are obesity,constipation,and red eye and swelling and pain.The biochemical indicator targets are hyperlipidemia and hypertension.Modern pharmacological studies have found that cassia seed and its active ingredients have the effects of lowering blood pressure,lowering blood lipids,protecting the retina,defecating,protecting liver,and anti-bacteria and so on.The main chemical components in cassia seed,such as emodin type anthraquinone compounds,have hepatorenal toxicity.In clinical use,attention should be paid to dosage compatibility to avoid causing or aggravating liver and kidney damage.The clinical dose is 3-60 g.When taken orally,it should be used dialectically according to different diseases or different stages of the same disease,and the construction of dose-effect relationship between the dosage of cassia seed and the symptom target and biomeidical indicator target should be explored actively.