外周血miR-143、miR-33a表达与膀胱癌患者临床预后的相关性

Correlation between the Expression of miR-143 and miR-33a in Peripheral Blood and the Clinical Prognosis of Bladder Cancer Patients

【目的】探讨外周血miR-143、miR-33a表达与膀胱癌患者临床预后的相关性。【方法】选取2017年5月至2021年4月本院收治的60例膀胱癌患者(观察组),另选取同期体检的60例健康志愿者作为对照组。比较两组研究对象外周血miR-143、miR-33a表达水平及不同病理特征患者外周血miR-143、miR-33a表达水平,评价外周血miR-143、miR-33a对膀胱癌的诊断价值,比较外周血miR-143、miR-33a不同表达膀胱癌患者生存曲线,分析外周血miR-143、miR-33a表达与膀胱癌患者死亡风险的关系。【结果】观察组患者外周血miR-143、miR-33a表达水平低于对照组患者,差异有统计学意义(P<0.05)。不同临床分期、组织分化程度、初发与复发及有无远处转移患者外周血miR-143、miR-33a表达水平比较,差异有统计学意义(P<0.05)。外周血miR-143、miR-33a联合诊断膀胱癌的曲线下面积为0.922,显著高于miR-143、miR-33a单一指标(P<0.05)。外周血miR-143、miR-33a低表达患者的术后3年生存率分别低于外周血miR-143、miR-33a高表达患者(P<0.05)。外周血miR-143、miR-33a低表达患者术后3年死亡风险是高表达患者的4.550倍、5.223倍(P<0.05)。【结论】膀胱癌患者miR-143、miR-33a表达下调,与病理特征密切相关,检测其表达水平有助于评估患者预后情况,具有较高临床价值。

【Objective】To investigate the relationship between the expression of miR-143 and miR-33a in peripheral blood and the clinical prognosis of bladder cancer patients.【Methods】A total of 60 patients with bladder cancer admitted to our hospital from May 2017 to April 2021(observation group)were selected,and 60 healthy volunteers who underwent physical examination in the same period were selected as the control group.The expression levels of miR-143 and miR-33a in the peripheral blood of the two groups of subjects and the expression levels of miR-143 and miR-33a in the peripheral blood of patients with different pathological characteristics were compared.The diagnostic value of miR-143 and miR-33a in the peripheral blood for bladder cancer was evaluated.The survival curves of bladder cancer patients with different expressions of miR-143 and miR-33a in the peripheral blood were compared.The relationship between the expression of miR-143 and miR-33a in the peripheral blood and the death risk of bladder cancer patients was analyzed.【Result】The expression levels of miR-143 and miR-33a in the peripheral blood of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).The expression levels of miR-143 and miR-33a in peripheral blood of patients with different clinical stages,degree of tissue differentiation,initial and recurrent stages,and presence or absence of distant metastasis were compared,and the differences were statistically significant(P<0.05).The area under the curve of miR-143 and miR-33a in the combined diagnosis of bladder cancer was 0.922,significantly higher than that of miR-143 and miR-33a(P<0.05).The postoperative 3-year survival rates of patients with low expression of miR-143 and miR-33a in peripheral blood were lower than those of patients with high expression of miR-143 and miR-33a in peripheral blood(P<0.05).The 3-year postoperative mortality risk of patients with low expression of miR-143 and miR-33a in peripheral blood is 4.550 times and 5.223 times higher than that of patients with high expression(P<0.05).【Conclusion】The expression of miR-143 and miR-33a in the peripheral blood of patients with bladder cancer is down regulated,which is closely related to the pathological characteristics.The detection of their expression level is helpful to evaluate the prognosis of patients,and has high clinical value.