湿润烧伤膏在儿童大面积鲜红斑痣激光治疗创面修复中的应用

Application of MEBO in the wound repair for children with large area port-wine stains treated by laser

目的观察湿润烧伤膏联合脉冲染料激光对提升儿童大面积鲜红斑痣整体治疗效果的影响,以期指导临床相关疾病治疗。方法本文为随机对照试验,研究对象选自2022年1月至2022年9月湖南省人民医院收治60例大面积鲜红斑痣患儿,采用随机数字表法将其分为两组,各30例。对照组男童12例,女童18例,年龄(6.25±1.02)岁;试验组男童10例,女童20例,年龄(6.35±1.05)岁。对照组采取595 nm脉冲染料激光治疗联合常规抗炎软膏护理创面,试验组采取595 nm脉冲染料激光联合湿润烧伤膏护理创面。对比两组治疗效果、红痣瘢痕消退程度[采用温哥华瘢痕量表(VSS)评估]、疼痛程度(采用国际数字疼痛分级标准评估)、不良反应。采用t检验、χ^(2)检验、秩和检验。结果试验组治疗总有效率高于对照组[96.67%(29/30)比70.00%(21/30)],差异有统计学意义(χ^(2)=7.680,P<0.05)。治疗结束时,试验组红痣瘢痕消退程度(VSS评分)低于对照组[(1.25±0.85)分比(4.02±1.12)分],差异有统计学意义(t=10.791,P<0.05);治疗结束时,试验组疼痛程度低于对照组[(1.02±0.25)比(3.02±0.52)],差异有统计学意义(t=18.986,P<0.05)。试验组不良反应总发生率低于对照组[10.00%(3/30)比43.33%(13/30)],差异有统计学意义(χ^(2)=8.523,P<0.05)。结论595 nm脉冲染料激光联合湿润烧伤膏可显著提高儿童大面积鲜红斑痣的治疗效果,利于红痣瘢痕消退,改善疼痛程度,提升患儿治疗过程中的舒适度,且安全可靠。

Objective To observe the effect of moisture exposed burn ointment(MEBO)combined with pulsed dye laser on enhancing the overall treatment effect of large area port-wine stains in children,and to guide the treatment of clinically relevant diseases.Methods This was a randomized controlled trial.A total of 60 children with large area port-wine stains admitted to Hunan Provincial People's Hospital from January 2022 to September 2022 were selected as the research objectives,and were divided into two groups using the random number table method,with 30 cases in each group.There were 12 boys and 18 girls in the control group,with an age of(6.25±1.02)years old.There were 10 boys and 20 girls in the experimental group,with an age of(6.35±1.05)years old.The control group received 595 nm pulsed dye laser treatment combined with conventional anti-inflammatory ointment to care for the wound,while the experimental group received 595 nm pulsed dye laser combined with MEBO to care for the wound.The treatment effect,degree of red nevus scar regression[evaluated using the Vancouver Scar Scale(VSS)],degree of pain(evaluated using the International Digital Pain Rating System),and adverse reactions were compared between the two groups.t test,χ^(2) test,and rank sum test were used.Results The total effective rate of the experimental group was higher than that of the control group[96.67%(29/30)vs.70.00%(21/30)],with a statistically significant difference(χ^(2)=7.680,P<0.05).At the end of treatment,the regression degree of nevus scar(VSS score)of the experimental group was lower than that of the control group[(1.25±0.85)points vs.(4.02±1.12)points],with a statistically significant difference(t=10.791,P<0.05).At the end of treatment,the pain degree of the experimental group was lower than that of the control group[(1.02±0.25)vs.(3.02±0.52)],with a statistically significant difference(t=18.986,P<0.05).The total incidence of adverse reactions in the experimental group was lower than that in the control group[10.00%(3/30)vs.43.33%(13/30)],with a statistically significant difference(χ^(2)=8.523,P<0.05).Conclusion MEBO combined with 595 nm pulsed dye laser can significantly improve the therapeutic effect of large area port-wine stains in children,which facilitates the subsidence of red nevus scar,improves the degree of pain,promotes the children's comfort in the process of treatment,and is safe and reliable.