盐酸阿夫唑嗪联合头孢克肟治疗儿童神经源性膀胱合并尿路感染的效果观察

Effect of afzosin hydrochloride combined with cefixime in the treatment of neurogenic bladder complicated with urinary tract infection in children

目的探究盐酸阿夫唑嗪联合头孢克肟治疗儿童神经源性膀胱合并尿路感染的应用效果。方法选取2018年5月~2023年4月收治的60例神经源性膀胱合并尿路感染患儿,按照随机数字法分为对照组(n=30)和研究组(n=30),其中对照组采用盐酸阿夫唑嗪进行治疗,研究组采用盐酸阿夫唑嗪联合头孢克肟治疗。比较两组炎症因子水平、临床症状改善情况、细胞计数情况,评估临床疗效。结果治疗后,研究组总有效率高于对照组,差异有统计学意义(P<0.05);治疗前,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平差异无统计学意义(P>0.05);治疗后,研究组TNF-α、IL-6、CRP水平低于对照组,差异有统计学意义(P<0.05);治疗前,两组每日间歇性导尿(IC)次数、膀胱剩余尿量(PVR)、膀胱漏尿点容积(LPV)、逼尿肌漏尿点压力(LPP)差异无统计学意义(P>0.05),治疗后,两组LPV水平差异无统计学意义(P>0.05),治疗后研究组每日IC次数、PVR、LPP均低于对照组,差异有统计学意义(P<0.05);治疗前,两组尿白细胞(WBC)计数、血白细胞(WBC)计数、血中性粒细胞计数差异无统计学意义(P>0.05),治疗后研究组尿WBC计数、血WBC计数、血中性粒细胞计数低于对照组,差异有统计学意义(P<0.05)。结论盐酸阿夫唑嗪联合头孢克肟应用于儿童神经源性膀胱合并尿路感染,可有效改善患儿的临床疗效,降低患儿血液中的炎症因子水平,同时有效降低患儿尿白细胞、血白细胞、血中性粒细胞计数水平。

Objective To investigate the effect of afzosin hydrochloride combined with cefixime in the treatment of neurogenic bladder complicated with urinary tract infection in children.Methods A total of 60 children with neurogenic bladder complicated with urinary tract infection enrolled in a hospital from May 2018 to April 2023 were divided into control group(n=30)and study group(n=30)according to random number method.The control group was treated with afzosin hydrochloride,and the study group was treated with afzosin hydrochloride combined with cefixime.The levels of inflammatory factors,improvement of clinical symptoms and cell count were compared between the two groups to evaluate the clinical efficacy.Results After treatment,the total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in TNF-α,IL-6 and CRP levels between the two groups(P>0.05).After treatment,the levels of TNF-α,IL-6 and CRP in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in IC times,PVR,LPV and LPP between the two groups(P>0.05).After treatment,there was no significant difference in LPV levels between the two groups(P>0.05),but the IC times,PVR and LPP in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in urine WBC count,blood WBC count and blood neutrophil count between the two groups(P>0.05).After treatment,the urine WBC count,blood WBC count and blood neutrophil count in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The application of afzosin hydrochloride combined with cefixime in children with neurogenic bladder complicated with urinary tract infection can effectively improve the clinical efficacy,reduce the levels of inflammatory factors in the blood,and effectively reduce the levels of urinary white blood cells,blood white blood cells and blood neutral particles.