血脂对早期钙化性主动脉瓣膜病的预测价值

The Prediction Value of Blood Lipids in Early Calcific Aortic Valve Disease

目的探讨血脂水平与早期钙化性主动脉瓣膜病(CAVD)的关系及血脂水平对早期CAVD的预测价值。方法采用回顾性分析方法选取我院心内科2021年1月至2021年12月住院患者315例,根据心脏彩超结果分为病例组(55例)及对照组(260例),收集所有研究对象临床基本信息及实验室空腹血脂检验指标,计算TG/HDL-C、TC/HDL-C、LDL-C/HDL-C、ApoB100/ApoA1值,采用SPSS 20.0统计软件进行统计分析。结果两组患者的性别、体质指数、吸烟、饮酒、糖尿病患病率、TG、TC、HDL-C、LDL-C、VLDL-C、ApoA1、ApoB100、TG/HDL-C、TC/HDL-C、LDL-C/HDL-C、ApoB100/ApoA1比较,差异无统计学意义(P>0.05)。与对照组比较,病例组年龄[(67.29±7.42)岁vs.(60.98±9.76)岁]、高血压患病率(65.45%vs.47.69%)、Lp(a)水平[(499.62±417.98)mg/L vs.(240.83±209.70)mg/L]明显高于对照组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,高龄(OR=1.081,95%CI 1.033~1.132,P=0.001)、高Lp(a)水平(OR=1.003,95%CI 1.002~1.004,P<0.001)是发生早期CAVD的独立危险因素。ROC曲线分析结果显示,Lp(a)(AUC 0.704,95%CI 0.626~0.781,P<0.0001),对早期CAVD有一定的预测价值。结论Lp(a)是发生早期CAVD的独立危险因素,其对患者发生早期CAVD具有预测价值。

Objective To explore the correlation between blood lipid level and early calcific aortic valve disease(CAVD)and the predictive value of blood lipid level for early CAVD.Methods A retrospective analysis method was used to select 315 inpatients in the Department of Cardiology from 2021.1~2021.12.According to the results of color Doppler echocardiography,they were divided into a case group(55)and a control group(260).Information and laboratory fasting blood lipid test indicators were collected,TG/HDL-C,TC/HDL-C,LDL-C/HDL-C,ApoB100/ApoA1 values were calculated,and SPSS 20.0 statistical software was used for statistical analysis.Results The difference of gender,body mass index,smoking,drinking,prevalence of diabetes,TG,TC,HDL-C,LDL-C,VLDL-C,ApoA1,ApoB100,TG/HDL-C,TC/HDL-C,LDL-C/HDL-C,ApoB100/ApoA1 was not statistically significant(P>0.05).Compared with the control group,the age of the case group[(67.29±7.42)vs.(60.98±9.76)],the prevalence of hypertension(65.45%vs.47.69%),the level of Lp(a)[(499.62±417.98)ng/L vs.(240.83±209.70)mg/L]were significantly higher than that of the control group,and the differences were statistically significant(P<0.05).Multivariate logistic regression analysis showed that the elderly(OR=1.081,95%CI 1.033~1.132,P=0.001),high Lp(a)level(OR=1.003,95%CI 1.002~1.004,P<0.001)were independent risk factors for early CAVD.ROC curve analysis showed that Lp(a)(AUC 0.704,95%CI 0.626~0.781,P<0.0001)might have a certain predictive value for early CAVD.Conclusion Lp(a)is an independent risk factor for early CAVD,and it has a predictive value for early CAVD in patients.