微针导入重组Ⅲ型人源化胶原蛋白在皮肤屏障功能修复中的应用效果

Application effect of microneedle introduction of recombinant type Ⅲ humanized collagen in the repair of skin barrier function

目的探究微针导入重组Ⅲ型人源化胶原蛋白治疗因皮肤炎性衰老导致的皮肤屏障功能下降的有效性及安全性。方法选取2020年6月至2021年5月在本院接受面部皮肤治疗的30例患者作为研究对象,采用随机数字表法将其分为对照组(重组Ⅲ型人源化胶原蛋白)与治疗组(微针导入重组Ⅲ型人源化胶原蛋白),各15例。治疗后定期对患者进行随访,分别进行主观疗效评价及客观疗效评价。结果治疗后4、8、12周,治疗组的满意度显著高于对照组(P<0.05)。治疗后,治疗组的皮肤皱纹、纹理、红区、毛孔、弹性、皮肤经皮失水及皮肤含水量改善明显(P<0.05);对照组治疗后油脂改善明显(P<0.05)。治疗后12周,治疗组的总症状评分显著低于对照组(P<0.05)。结论微针导入重组Ⅲ型人源化胶原蛋白对皮肤修复有较好的疗效,可增强皮肤屏障功能,为改善皮肤屏障功能、治疗因皮肤屏障受损引起的炎性衰老提供了新选择。

Objective To explore the efficacy and safety of microneedle introduction of recombinant typeⅢ humanized collagen in the treatment of skin barrier function decline caused by skin inflammatory aging.Methods Thirty patients who received facial skin treatment in our hospital from June 2020 to May 2021 were selected as the research objects,and the patients were divided into control group(recombinant type Ⅲ humanized collagen)and treatment group(microneedle introduction of recombinant type Ⅲ humanized collagen)by random number table method,with 15 cases in each group.After treatment,the patients were followed up regularly,and the subjective efficacy evaluation and objective efficacy evaluation were carried out respectively.Results At 4,8 and 12 weeks after treatment,the satisfaction of the treatment group was significantly higher than that of the control group(P<0.05).After treatment,the skin wrinkles,texture,red area,pores,elasticity,skin transcutaneous loss water and skin water content of the treatment group significantly improved(P<0.05);the oil of the control group improved significantly after treatment(P<0.05).At 12 weeks after treatment,the total symptom score of the treatment group was significantly lower than that of the control group(P<0.05).Conclusion The microneedle introduction of recombinant type Ⅲ humanized collagen has a good effect on skin repair,which can enhance the function of skin barrier,and provides a new choice for improving the function of skin barrier and treating inflammatory aging caused by damaged skin barrier.