HIE新生儿血清内B淋巴细胞和NLR水平与病情进展程度及预后的相关性

The correlation between the level of B-lymphocyte and NLR in the serum of HIE newborns and the degree of disease progression and prognosis

目的:探讨新生儿缺氧缺血性脑病血清内B淋巴细胞和NLR水平与病情进展程度及预后的相关性。方法:选取商丘市第一人民医院2020年3月至2022年3月诊断的120例新生儿缺氧缺血性脑病患儿作为疾病组,根据新生儿窒息的脑损伤情况分析,其中轻度患儿48例,中度患儿41例,重度患儿31例,另选取同期健康新生儿120例作为对照组,比较疾病组与对照组、不同严重程度以及不同预后患者的NLR、CD19^(+)、CD19^(+)CD25^(+)水平之间的差异,分析血清内B淋巴细胞和NLR水平与病情进展程度及预后的相关性。结果:疾病组患儿的NLR水平显著高于对照组,CD19^(+)、CD19^(+)CD25^(+)水平显著低于对照组(P<0.05);不同严重疾病患儿的NLR、CD19^(+)、CD19^(+)CD25^(+)水平之间的差异无统计学意义(P>0.05),经过两两比较,CD19^(+)、CD19^(+)CD25^(+)水平从高到低依次为轻度、中度以及重度,NLR水平从高到低依次为重度、中度以及轻度(P<0.05);预后不良组患儿的NLR水平显著高于预后良好组,CD19^(+)、CD19^(+)CD25^(+)水平显著低于预后良好组(P<0.05);通过相关性分析,患儿的预后不良以及疾病严重程度与NLR呈现正相关,与CD19^(+)、CD19^(+)CD25^(+)水平呈现负相关(P<0.05);针对预后不良患儿,联合诊断的灵敏度显著高于单独检测,同时,通过对ROC曲线分析,预后不良患儿的NLR、CD19^(+)、CD19^(+)CD25^(+)水平分别为3.50,16.33,0.54。结论:HIE新生儿血清内B淋巴细胞和NLR水平与病情进展程度及预后呈现显著相关性,未来可通过对患儿的B淋巴细胞和NLR水平对患儿的不良预后进行有效预测。

Objective:To explore the correlation between the level of B lymphocyte and NLR in the serum of neonates with hypoxic-ischemic encephalopathy(HIE)and the degree of disease progression and prognosis.Methods:120 neonates with hypoxic-ischemic encephalopathy diagnosed by our hospital from March 2020 to March 2022were selected as the research objects.According to the analysis of the brain injury of neonatal asphyxia,48 were mild,41 were moderate and 31 were severe.Another 120 healthy newborn infants were selected as the control group to compare the disease group with the control group,different severity and different prognosis The differences of NLR,CD19^(+)and CD19^(+)CD25^(+)were analyzed.The correlation between the level of B lymphocyte and NLR in serum and the progression of disease and prognosis was analyzed.Results:The level of NLR in the disease group was significantly higher than that in the control group,and the levels of CD19^(+),CD19^(+)CD25^(+)were significantly lower than that in the control group(P The level of NLR in the group with poor prognosis was significantly higher than that in the group with good prognosis(P The sensitivity of combined diagnosis was significantly higher than that of single detection.At the same time,the levels of NLR,CD19^(+)and CD19^(+)CD25^(+)were 3.50,16.33 and 0.54 respectively.Conclusion:The level of B-lymphocyte and NLR in the serum of HIE neonates is significantly correlated with the degree of disease progression and prognosis.In the future,the level of B-lymphocyte and NLR can effectively predict the poor prognosis of HIE neonates.