冠心宁对冠心病舒张性心力衰竭患者血清转化生长因子β1及结缔组织生长因子的影响

Effect of Guanxinning on Transforming Growth Factor β1 and Connective Tissue Growth Factor in Serum in Patients with Diastolic Heart Failure of Coronary Heart Disease

目的:观察冠心宁对冠心病舒张性心力衰竭(DHF)患者血清转化生长因子-β1(TGF-β1)、结缔组织生长因子(CTGF)的影响。方法:选取100例DHF患者,按随机数字表法分为常规组及治疗组各50例。常规组采用强心、利尿、扩管等基础治疗,治疗组在常规组治疗基础上加用冠心宁片。比较2组临床疗效及不良反应发生率,比较2组治疗前后TGF-β1、CTGF水平、Lee氏心衰评分、改良早期预警量表(MEWS)评分的变化,进行Pearson相关性分析。结果:治疗组临床总有效率为96.00%,常规组为84.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组TGF-β1、CTGF水平均较治疗前下降(P<0.05),治疗组TGF-β1、CTGF水平均低于常规组(P<0.05)。治疗后,2组Lee氏心衰评分、MEWS评分均较治疗前下降(P<0.05),治疗组Lee氏心衰评分、MEWS评分均低于常规组(P<0.05)。Pearson相关性分析结果显示,Lee氏心衰评分、MEWS评分与TGF-β1、CTGF的表达水平均呈正相关。其中Lee氏心衰评分与TGF-β1呈中度相关,与CTGF呈高度相关,MEWS评分与TGF-β1、CTGF均呈正相关。常规组不良反应发生率为16.00%,治疗组为6.00%,2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:冠心宁治疗冠心病DHF可提升疗效,改善患者的病情及预后,安全性高。

Objective:To observe the effect of Guanxinning on transforming growth factor-β1(TGF-β1)and connective tissue growth factor(CTGF) in serum in patients with diastolic heart failure(DHF) of coronary heart disease.Methods:A total of 100 cases of DHF patients were selected and divided into the routine group and the treatment group according to the random number table method,with 50 patients in each group.The routine group was given basic treatment like strengthening heart,promoting urination and expanding tubes,and the treatment group was additionally treated with Guanxinning Tablets based on treatment of the routine group.The clinical effects and the incidence of adverse reactions were compared between the two groups;the changes in the levels of TGF-β1 and CTGF,Lee's heart failure scores and Modified Early Warning Scale(MEWS) scores were compared before and after treatment between the two groups,and Pearson correlation analysis was performed.Results:The total clinical effective rate was96.00% in the treatment group and 84.00% in the routine group,the difference being significant(P<0.05).After treatment,the levels of TGF-β1 and CTGF in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of TGF-β1 and CTGF in the treatment group were lower than those in the routine group(P<0.05).After treatment,Lee's heart failure scores and MEWS scores in the two groups were decreased when compared with those before treatment(P<0.05),and Lee's heart failure score and MEWS score in the treatment group were lower than those in the routine group(P<0.05).Pearson correlation analysis showed that Lee's heart failure score and MEWS score were positively correlated with TGF-β1 and CTGF expression levels.Lee's heart failure score was moderately correlated with TGF-β1 and highly correlated with CTGF,and MEWS score was positively correlated with TGF-β1and CTGF.The incidence of adverse reactions was 16.00% in the routine group and 6.00% in the treatment group,there being no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Guanxinning for patients with DHF of coronary heart disease can enhance the curative effect and improve the condition and prognosis of patients,with high safety.