珍黄安宫片联合抗癫痫药物治疗痰火扰神型癫痫的效果

Effect of Zhenhuang Angong Tablets Combined with Anti-epileptic Drugs on the Treatment of Phlegm-fire Distur⁃bance Epilepsy

目的:探究珍黄安宫片联合抗癫痫药物治疗痰火扰神型癫痫的效果。方法:选取2020年3月—2023年3月大连市第三人民医院收治的痰火扰神型癫痫患者106例为研究对象,以随机数字表法分为对照组(n=53,抗癫痫药物治疗)和观察组(n=53,珍黄安宫片联合抗癫痫药物治疗)。比较两组临床疗效、氧化应激指标情况,统计患者癫痫发作情况及药物不良反应发生率。结果:观察组临床疗效总有效率高于对照组,差异有统计学意义(P=0.038);治疗后,两组一氧化氮(NO)、超氧化物歧化酶(SOD)水平高于治疗前,丙二醛(MDA)水平低于治疗前,且观察组NO、SOD水平高于对照组,MDA水平低于对照组,差异有统计学意义(P<0.05);治疗后,两组癫痫发作频率及癫痫发作持续时间均较治疗前下降,且观察组低于对照组,差异有统计学意义(P<0.05);两组药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论:珍黄安宫片联合抗癫痫药物治疗痰火扰神型癫痫疗效显著,能够改善患者氧化应激水平,减少癫痫发作,缩短癫痫发作时间,安全性较高。

Objective:To explore the effect of Zhenhuang Angong tablets combined with anti-epileptic drugs in the treatment of phlegm-fire disturbance epilepsy.Methods:A total of one hundred and six patients with phlegm-fire disturbance epilepsy treated in Dalian Third People's Hospital from March 2020 to March 2023 were selected as the study objects,and were divided into control group(n=53,anti-epileptic drug treatment)and observation group(n=53,Zhenhuang Angong tablets combined with anti-epileptic drug treatment)by random number table method.The clinical efficacy and oxidative stress indexes of the two groups were compared,and the incidence of epileptic seizures and adverse drug reactions were counted.Results:The total effective rate of observation group was higher than that of control group,the difference was statistically significant(P=0.038);After treatment,the levels of nitric oxide(NO)and superoxide dismutase(SOD)in 2 groups were higher than before treatment,and the level of malondialdehyde(MDA)was lower than before treatment,and the levels of NO and SOD in observation group were higher than those in control group,and the level of MDA was lower than that in control group,with statistical significance(P<0.05);After treatment,the frequency and duration of seizures in both groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion:Zhenhuang Angong tablets combined with antiepileptic drugs have a significant effect on the treatment of phlegm-fire disturbance epilepsy,improve the level of oxidative stress,reduce epilepsy,shorten the duration of epilepsy,and have high safety.