常见组蛋白修饰调控滋养层细胞谱系分化的研究进展

Research progress of common histone modification regulating trophoblast cell lineage differentiation

胎盘是决定妊娠建立及维持胎儿正常生长发育的重要器官,其介导了母胎间的复杂对话。滋养层细胞是执行胎盘功能的一类重要细胞类型,在胎盘发育过程中,滋养层干细胞可分化为多种滋养层细胞亚型,从而维持胎盘的结构和功能。组蛋白修饰可通过调控染色质的结构及基因转录参与滋养层细胞谱系的建立和维持。本文系统性总结了重要组蛋白甲基化及乙酰化修饰调控滋养层干细胞分化及胎盘发育的复杂作用及机制。

Placenta serves as an important organ,which determines the establishment of pregnancy and intrauterine fetal growth,as well as the complex maternal-fetal crosstalk.Different subtypes of trophoblast cells mediate the diverse functions of the placenta.During placental development,the trophectoderm-derived trophoblast stem cells differentiate into all subtypes of trophoblasts and thus maintaining the structure and function of the placenta.Histone modifications can regulate chromatin structure and gene transcription,which is involved in the establishment,maintenance and differentiation of trophoblast lineage.In this review,we systemically overview the indispensable roles of histone methylation and acetylation in trophoblast differentiation.