肾移植患者霉酚酸暴露量预测公式比较

Effects of formulas on prediction of mycophenolic acid exposure among renal transplantation patients:a comparative study

目的比较目前已报道的12个基于有限采样策略的霉酚酸暴露量预测公式在我院肾移植患者霉酚酸暴露量中的预测效果。方法入组20例口服吗替麦考酚酯分散片的肾移植患者,采集不同时间的全血样本,使用二维液相色谱测定霉酚酸血药浓度。采用WinNonlin软件计算霉酚酸的药代动力学参数。运用12个预测公式预测霉酚酸AUC0~12h,计算预测值与实测值的相关系数(R2)值、预测AUC0~12h平均相对预测误差和理想预测AUC0~12h占比。结果公式8的预测AUC0~12h与MPA-AUC0~12h相关性较好,R2=0.923,平均预测误差绝对值最小(约为12.00),预测AUC0~12h在理想预测范围内的占比最高(80%)。结论预测公式8在估算我院肾移植患者霉酚酸暴露量中有良好的预测效果。

Objective To compare the efficacies of 12 prediction formulas for mycophenolic acid exposure established based on limited sampling strategies in prediction of mycophenolic acid exposure among the renal transplantation patients in the hospital.Methods A total of 20 renal transplantation patients who were treated with oral administration of mycophenolate mofetil were enrolled in the study,and the whole blood samples were collected at different time points.The plasma mycophenolic acid(MPA)concentrations were detected by two-dimensional liquid chromatography.The pharmacokinetic parameters of mycophenolic acid were calculated by WinNonlin software.The AUC0-12 h of mycophenolic acid was predicted by the 12 prediction formulas,and the 2 correlation coefficient R between the predicted value and the measured value was calculated,the average relative prediction error of predicted AUC0-12h and the proportion of AUC0-12 h were predicted.Results There was a significant correlation between the AUC0-12 h 2 predicted by formula 8 and MPA-AUC0-12 h,R=0.923;the absolute value of the average prediction error was the least(about 12.00),and the predicted AUC0-12 h occupied the highest proportion among the ideal prediction range(80%).Conclusion The prediction formula 8 shows remarkable effect on prediction of mycophenolic acid exposure among the renal transplantation patients in the hospital.