尿微量白蛋白与尿肌酐比值、尿视黄醇结合蛋白及尿β2微球蛋白联合检测对糖尿病肾病的诊断价值

Diagnostic Value of Combined Detection of Alb To Creatinine Ratio,Urinary Retinol Binding Protein,Urine Β2 Microglobulin for Diabetes Nephropathy

目的 探讨尿微量白蛋白与尿肌酐比值(ACR)、尿视黄醇结合蛋白(RBP)及尿β2微球蛋白(β2-MG)联合检测对糖尿病肾病的诊断价值。方法 对2022年1月—2023年6月本院收治的2型糖尿病(T2DM)患者200例临床资料进行回顾性分析,根据是否有糖尿病肾病分为肾病组(100例)、单纯糖尿病(DM)组(100例),均接受ACR、RBP及β2-MG联合检测,对检测结果进行分析。结果 肾病组ACR、RBP、β2-MG水平与单纯糖尿病组比较有明显差异(P<0.05);肾病组患者不同Mogensen分期患者的尿微量白蛋白/尿肌酐比值、尿视黄醇及尿β2微球蛋白水平比较有明显差异(P<0.05);单项检测的诊断特异度、灵敏度明显较联合检测低(P<0.05)。结论 ACR、RBP、β2-MG联合检测对糖尿病肾病具有较高的检测价值,在出现早期肾损伤时即可检出,也有助于评估肾病程度,为临床制定治疗方案提供参考依据。

Objective To explore diagnostic value of combined detection of Alb to creatinine ratio(ACR),urinary retinol binding protein(RBP),and urine β2-microglobulin for diabetes nephropathy.Methods The paper reviewed and analyzed clinical data of 200 patients with type 2 diabetes(T2DM)admitted to our hospital from January 2022 to June 2023,and divided them into groups according to codition of diabetes nephropathy,100 cases in nephrosis group,100 cases in simple diabetes(DM)group,all treated with combined detection of ACR,RBP and β2-MG,and analyze detection result.Results ACR,RBP,and β2-MG levels were significantly different from simple diabetes group(P<0.05).Urinary microalbumin/creatinine ratio,urinary retinol,and urine β2-microglobulin leveles of patients with different Mogensen stages of kidney disease group showed significant difference,(P< 0.05).Diagnostic specificity and sensitivity of single detection was significantly lower than combined detection(P<0.05).Conclusion Combined detection of ACR,RBP 、β2-MG has high detection value for diabetes nephropathy,can detect early renal injury,help evaluate degree of nephropathy,and provide reference for clinical treatment.