血常规结合凝血六项检验在孕妇临床妊娠期间应用研究

Study on the Application of Blood Routine Examination Combined with Blood Coagulation Test in Pregnant Women During Clinical Pregnancy

目的探讨血常规结合凝血六项检验在孕妇妊娠期的应用价值。方法选取于2022年2月至2023年6月在洛阳市妇幼保健院进行产检的102例孕妇作为研究组,并选择同期入院的30例非妊娠期女性作为对照组,回顾性分析所有研究对象的临床资料,统计两组血常规与凝血六项检验结果,并比较研究组不同妊娠期孕妇的血常规与凝血六项检验结果。结果研究组与对照组的血小板计数(PLT)相比,差异无统计学意义(P>0.05);研究组红细胞计数(RBC)、血红蛋白(Hb)、红细胞平均体积(MCV)、凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)均低于对照组,而红细胞分布宽度变异系数(RDW-CV)、白细胞计数(WBC)、纤维蛋白原(FIB)、D-二聚体(D-D)、纤维蛋白降解产物(FDP)水平均高于对照组,差异具有统计学意义(P<0.05)。不同孕期孕妇的PLT与PT相比,差异无统计学意义(P>0.05);孕中、孕晚期孕妇的RBC、Hb、MCV、TT、APTT均低于孕早期,而RDW-CV、WBC、FIB、D-D及FDP水平均高于孕早期,差异具有统计学意义(P<0.05)。结论孕妇血常规与凝血六项指标和非妊娠期女性间存在一定差异,且孕中期、孕晚期孕妇血常规与凝血六项变化程度往往较孕早期更为显著,临床应注意监测孕妇在不同妊娠期相关指标的变化情况,以免其发生异常波动而威胁母婴安全。

Objective To discuss the applied value of blood routine examination combined with six blood coagulation test in the pregnant women during pregnancy.Methods A total of 102 pregnant women who underwent obstetric examination in Luoyang Maternal and Child Health Hospital from February 2022 to June 2023 were selected as the study group,and 20 non-pregnant women admitted to the hospital during the same period of same were selected as the control group.The clinical data of all the study subjects were retrospectively analyzed,and the results of routine blood and coagulation tests of the two groups were statistically analyzed and the results of routine blood and coagulation test were compared with those of the pregnant women of different gestation periods in the study group.Results The differences in blood platelet counts(PLT)between the research group and the control group were not significantly different(P>0.05);the red blood cell count(RBC),hemoglobin(Hb),mean corpuscular volume of erythrocytes(MCV),prothrombin time(PT),thrombin time(TT)and activated partial prothrombin time(APTT)in the research group were significantly lower than in the group;whereas the coefficients of variation for red blood cell distribution width(RDW-CV),white blood cell count(WBC),fibrinogen(FIB),D-dimer(D-D),and fibrin degradation product(FDP)levels were higher than those of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference between PLT and PT of pregnant women in different trimesters(P>0.05);RBC,Hb,MCV,TT and APTT of pregnant women in the middle and late trimesters were lower than those in the early trimester,while the levels of RDW-CV,WBC,FIB,D-D and FDP were higher than those in the early trimester,and the difference was statistically significant(P<0.05).Conclusion The blood routine examination and blood coagulation test results are found to be statistically significant between gestational and non-gestational women.Moreover,blood routine and coagulation abnormalities in pregnant women in the middle and late stages of pregnancy are often more significant than in the early stages of pregnancy.Clinical attention should be paid to monitoring the changes of relevant indicators of pregnant women in different gestation periods to avoid abnormal fluctuations that may threaten the safety of mothers and infants.