华佗再造丸辅助丁苯酞注射液对脑卒中患者神经功能缺损及血流动力学的影响

Effect of Huatuo Zaizao Wan combined with Bu Phthalide Injection on neurological deficits and hemodynamics in stroke patients

目的:研究华佗再造丸辅助丁苯酞注射液对脑卒中患者神经功能缺损及血流动力学的影响.方法:以随机对照法将我院2020年3月至2022年3月确诊的脑卒中患者88例分为研究组(44例)、参照组(44例).参照组行丁苯酞注射液等治疗,研究组在参照组基础上行华佗再造丸治疗.治疗2 w后,比较两组临床疗效、神经功能、血流动力学、凝血功能、炎症因子水平.结果:治疗2 w后研究组总有效率高于参照组(P<0.05);治疗2 w后研究组各神经功能量表评分改善程度优于参照组;治疗2 w后研究组搏动指数低于参照组,收缩期峰值血流速度、平均血流速度高于参照组(P<0.05);治疗2 w后研究组D-二聚体水平低于对照组,凝血酶时间、凝血酶原时间、部分活化凝血活酶时间改善水平优于参照组(P<0.05);治疗2 w后研究组超敏C反应蛋白、同型半胱氨酸、肿瘤坏死因子-α水平均低于参照组(P<0.05).结论:华佗再造丸辅助丁苯酞注射液治疗脑卒中患者,可改善凝血功能及脑血流动力学,促进神经功能恢复,降低炎症水平,提高临床疗效.

Objective:To study the effects of Huatuo Zaizao Wan and Butylphthalein Injection on neurological deficits and hemodynamics in stroke patients.Methods:88 stroke patients diagnosed in our hospital from March 2020 to March 2022 were divided into a study group(44 cases)and a reference group(44 cases)using a randomized controlled method.The reference group received treatment with butylphthalide injection,while the research group received treatment with Huatuo Zaizao Wan on the basis of the reference group.After 2 weeks of treatment,compare the clinical efficacy,neurological function,hemodynamics,coagulation function,and inflammatory factor levels between the two groups.Results:After 2 weeks of treatment,the total effective rate of the study group was higher than that of the reference group(P<0.05);After 2 weeks of treatment,the improvement degree of each neurological function scale score in the study group was better than that in the reference group;After 2 weeks of treatment,the pulsatile index of the study group was lower than that of the reference group,while the peak systolic blood flow velocity and average blood flow velocity were higher than those of the reference group(P<0.05);Two weeks after treatment,the level of D-dimer in the study group was lower than that in the control group,and the improvement level of thrombin time,Prothrombin time,and partially activated thromboplastin time in the study group was better than that in the control group(P<0.05);Two weeks after treatment,the study group had high sensitivity C-reactive protein(hs CRP),homocysteine(Hcy),tumor necrosis factor-αTumor Necrosis factor-α(TNF-α),All levels were lower than the reference group(P<0.05).Conclusion:The treatment of stroke patients with Huatuo Zaizao Wan and Bu Phthalide Injection can improve coagulation function and cerebral hemodynamics,promote neurological recovery,reduce inflammation levels,and improve clinical efficacy.