面向阿尔茨海默病的非侵入性光生物调节治疗

Non-invasive Photobiomodulation Therapy for Alzheimer’s Disease

据我国阿尔茨海默病协会官方网站显示,在我国60岁及以上老年人中约有1500万痴呆患者,其中1000万是阿尔茨海默病患者。随着我国人口结构老龄化,这一数据还将不断攀升。目前,按照现代医学寻找治疗靶点的逻辑思路,尚无有效治疗阿尔茨海默病的因应对策,药物治疗有许多限制,外科手术也无能为力。对此,我们不得不重新思考传统的系统化、整体化和功能化观点,并针对产生阿尔茨海默病背后的先导因素采取相应的治疗策略。近年来,关于光生物调节(PBM)治疗神经退行性疾病的研究逐渐增多,越来越多的学者尝试采用非侵入性PBM方式延缓、抑制,甚至逆转神经元退行性病变。在神经疾病治疗方面,PBM作为一种新的治疗方式,具有无创伤、无副作用、可以调节氧自由基浓度、激活干细胞调节细胞转录、刺激神经递质分泌、激发突触与神经元生长等显著优点。这些优点是其他治疗方式无与伦比的。本文综述了现代医学关于阿尔茨海默病治疗的靶点,阐释了PBM治疗阿尔茨海默病的机制,从动物模型、临床试验、病理与细胞模型方面系统总结了PBM治疗阿尔茨海默病的进展,并对未来发展做出展望,旨在为探索阿尔茨海默病临床干预新措施以及发展先进治疗方法和医疗器械提供参考。

According to the official website of the Alzheimer’s Disease Association of China,there are about 15 million dementia patients in the elderly aged 60 and over in China,of which 10 million are Alzheimer’s patients.With the aging of China’s structural population,this data will continue to rise.At present,according to the logic of modern medicine to find therapeutic targets,there is no effective treatment for Alzheimer’s disease.There are many limitations in drug treatment,and surgery is powerless.In this regard,we have to rethink the traditional systematic,holistic and functional point of view,and take corresponding treatment strategies for the leading factors behind Alzheimer’s disease.In recent years,research on photobiomodulation(PBM)in the treatment of neurodegenerative diseases has gradually increased.More and more scholars have tried to use non-invasive PBM to delay,inhibit,and even reverse neurodegenerative diseases.In the treatment of neurological diseases,PBM,as a new treatment method,has significant advantages such as non-invasive,no side effects,regulation of oxygen free radical concentration,activation of stem cells to regulate cell transcription,stimulation of neurotransmitter secretion,and stimulation of synapse and neuron growth.These advantages are unmatched by other treatments.This paper reviews the targets of modern medicine for the treatment of Alzheimer’s disease,explains the mechanism of PBM in the treatment of Alzheimer’s disease,and systematically summarizes the progress of PBM in the treatment of Alzheimer’s disease from animal models,clinical trials,pathology and cell models,and looks forward to the future development,aiming to provide reference for exploring new clinical intervention measures for Alzheimer’s disease and developing advanced treatment methods and medical devices.